mirna在IBD中与肠上皮紧密连接屏障调节相关的炎症通路中的功能作用

IF 0.2 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Postȩpy higieny i medycyny doświadczalnej Pub Date : 2022-01-01 DOI:10.2478/ahem-2022-0038

Błażej Ochman, A. Kula, E. Świętochowska

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引用次数: 0

摘要

炎症性肠病——克罗恩病和溃疡性结肠炎——是一种免疫介导的慢性疾病，其复杂的发病机制和病理生理机制尚未完全阐明。肠上皮屏障(IEB)失调是IBD炎症过程诱导的主要潜在机制之一。适当的IEB完整性在很大程度上是由细胞间紧密连接维持的，细胞间紧密连接的功能可以被包括mirna在内的许多分子修饰。mirna属于非编码和非信使rna，可以通过结合预测mrna来调节基因表达。在这篇综述中，我们总结和讨论了mirna在IBD中影响肠上皮屏障功能的炎症信号通路调控中的潜在作用，特别强调了治疗潜力。综述的目的也是为了确定miRNA在IBD中肠上皮屏障调节研究的进一步发展方向。

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The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD

Abstract Inflammatory bowel disease – Crohn's disease and ulcerative colitis – is an immune-mediated chronic disorder with still not fully elucidated complex mechanisms of pathogenesis and pathophysiology. Intestinal epithelial barrier (IEB) dysregulation is one of the major underlying mechanisms of inflammatory process induction in IBD. Proper IEB integrity is maintained to a large extent by intercellular tight junctions, the function of which can be modified by many molecules, including miRNAs. MiRNAs belong to noncoding and non-messenger RNAs, which can modulate gene expression by binding predicted mRNAs. In this review, we summarize and discuss the potential role of miRNAs in the regulation of inflammatory signaling pathways affecting the function of the intestinal epithelial barrier in IBD, with particular emphasis on therapeutic potentials. The aim of the review is also to determine the further development directions of the studies on miRNA in the modulation of the intestinal epithelial barrier in IBD.

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来源期刊

Postȩpy higieny i medycyny doświadczalnej MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Advances in Hygiene and Experimental Medicine (PHMD) is a scientific journal affiliated with the Institute of Immunology and Experimental Therapy by the Polish Academy of Sciences in Wrocław. The journal publishes articles from the field of experimental medicine and related sciences, with particular emphasis on immunology, oncology, cell biology, microbiology, and genetics. The journal publishes review and original works both in Polish and English. All journal publications are available via the Open Access formula in line with the principles of the Creative Commons licence.