白化大鼠抗炎降糖作用的研究

Q3 Pharmacology, Toxicology and Pharmaceutics

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI:10.23893/1307-2080.aps.05726

Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi

{"title":"白化大鼠抗炎降糖作用的研究","authors":"Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi","doi":"10.23893/1307-2080.aps.05726","DOIUrl":null,"url":null,"abstract":"Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti-inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Investigation of the anti-inflammatory and hypoglycaemic effects of macaranga hurifolia beille (eurphorbiaceae) extract on wistar albino rats\",\"authors\":\"Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi\",\"doi\":\"10.23893/1307-2080.aps.05726\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti-inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia.\",\"PeriodicalId\":6962,\"journal\":{\"name\":\"ACTA Pharmaceutica Sciencia\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACTA Pharmaceutica Sciencia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23893/1307-2080.aps.05726\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACTA Pharmaceutica Sciencia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23893/1307-2080.aps.05726","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 1

摘要

大戟科(Macaranga hurifolia Beille)在尼日利亚民族植物学中用于治疗几种疾病。本实验旨在测定胡芦巴枯提取物(MHE)的植物化学成分，并研究其抗炎和降血糖活性。采用鸡蛋白蛋白炎症模型和四氧嘧啶诱导的糖尿病大鼠模型，分别评价MHE的抗炎和降糖作用。MHE对水肿的抑制具有剂量依赖性和时间依赖性，在300 mg/kg剂量时效果最大(69.6%)。急性体内抗糖尿病研究显示，MHE在200mg /kg(降低54%)和400mg /kg(降低59%)剂量下产生显著的降糖作用，与格列本脲(5mg /kg)的降糖效果相当，后者降低42%，而在慢性研究中，所有治疗组的血糖水平都至少降低25%。本研究首次证实了胡缕兰的抗炎和降糖作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Investigation of the anti-inflammatory and hypoglycaemic effects of macaranga hurifolia beille (eurphorbiaceae) extract on wistar albino rats

Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti-inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ACTA Pharmaceutica Sciencia Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sciencia (Acta Pharm. Sci.), formerly known as Bulletin of Pharmacy and Acta Pharmaceutica Turcica is a peer-reviewed scientific journal publishing current research and reviews covering all fields of pharmaceutical sciences since 1953. The original studies accepted for publication must be unpublished work and should contain data that have not been published elsewhere as a whole or a part. The reviews must provide critical evaluation of the state of knowledge related with the subject. All manuscripts has to be written in clear and concise English. Starting from 2016, the journal will be issued quarterly both in paper and on-line formates also publish special issues for national or international scientific meetings and activities in the coverage field.