Oral squamous cell carcinoma with pseudo- glandular differentiation

Conventional oral squamous cell carcinomas are readily recognized histopathologically but the presence of additional atypical features may be challenging from a diagnostic point of view. We present a case of a welldifferentiated oral squamous cell carcinoma with pseudoglandular differentiation and discuss the possible differential diagnoses on a histopathological basis. Accurate diagnosis is imperative for timely and appropriate intervention and denotes distinctive prognostic implications. The presence of perivascular and perineural infiltrations as observed in this case would indicate the need for further post-operative therapeutic decision-making aimed at controlling local spread as well as distant metastases.