基于2,4,6-三氯嘧啶-5-乙醛区域选择性功能化的绿色化学原理:在新嘧啶和吡咯嘧啶合成中的应用

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Journal of The Serbian Chemical Society Pub Date : 2022-01-01 DOI:10.2298/jsc210804063u

Allu Udayasri, Manchikanti Chandrasekhar, Brahmeswararao Naga, Ganesh Varanasi, D. Ramakrishna

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引用次数: 3

摘要

本文报道了三个新的含氮杂核分子(两个嘧啶和一个吡咯嘧啶)的合成。基于绿色化学的12条原则，化学方法被规划和执行。在形成C-N键的关键步骤(通过SnAr机制)中考察了各种相转移催化剂，发现TBAI比TBand CTAB更好。优化了Wittig烯烃和溴化的一锅合成方法，获得了合成新型吡咯嘧啶的关键前驱体。

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Green chemical principles based regioselective functionalization of 2,4,6-trichloropyrimidine-5-carbaldehyde: Application in the synthesis of new pyrimidines and pyrrolopyrimidine

The present work reports the synthesis of three new nitrogen-containing heteronuclear molecules (two pyrimidines and one pyrrolopyrimidine). Based on the 12 principles of green chemistry, chemical methodologies are planned and executed. Various phase transfer catalysts were examined in the crucial step to execute C-N bond formation (through SnAr mechanism), TBAI was found to be a better option than that of TBand CTAB. The one-pot synthetic methodology was optimized involving Wittig olefination and bromination to achieve a key precursor for the synthesis of a new pyrrolopyrimidine.

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来源期刊

Journal of The Serbian Chemical Society 化学-化学综合

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of the Serbian Chemical Society -JSCS (formerly Glasnik Hemijskog društva Beograd) publishes articles original papers that have not been published previously, from the fields of fundamental and applied chemistry: Theoretical Chemistry, Organic Chemistry, Biochemistry and Biotechnology, Food Chemistry, Technology and Engineering, Inorganic Chemistry, Polymers, Analytical Chemistry, Physical Chemistry, Spectroscopy, Electrochemistry, Thermodynamics, Chemical Engineering, Textile Engineering, Materials, Ceramics, Metallurgy, Geochemistry, Environmental Chemistry, History of and Education in Chemistry.