老年人心脏药物选择的临床影响因素综述

B. Foroutan
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引用次数: 0

摘要

衰老是自然生命周期的一个阶段。它是所有器官和身体系统经历的一套自然和协调的生长变化。由于两个原因,确定确切的老年时间是不可能的。首先,由于个体的遗传因素,人类的衰老过程是不同的。其次,老龄化有一系列生理、心理和社会因素。本综述旨在为临床医生在老年患者中使用心脏药物时收集适当的临床信息和事实,防止潜在的不适当做法。由于老年人排便减少,心脏药物的吸收会减少。在老年人中,流向整个胃肠道的血液减少,因此,进入一般血液的药物减少。延迟吸收会削弱药物的效力,同时延长其效果。这些影响可能是不安全的,因为大多数心脏药物的治疗指数都很窄。我们将回顾影响α和β受体阻滞剂、硝酸盐、cccb、ACE-Is、利尿剂和地高辛选择的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review of Clinical Influencing Factors in the Selection of Cardiac Medications in the Elderly
Aging is a stage of the natural life cycle. It is a set of natural and coordinated growth changes all organs and body systems undergo to burnout. It is impossible to determine the exact time of old age for two reasons. First, the aging process is different for humans due to individual, hereditary factors. Second, aging has a set of physiological, psychological and, social factors. This review aimed to gather appropriate clinical information and facts for clinicians when practicing heart medications in elderly patients, preventing potentially inappropriate practices. The absorption of heart medications decreases due to diminished bowel movements in the elderly. In the elderly, the blood flows to the entire gastrointestinal tract decreases and as a result, the entry of the medications into the general bloodstream decreases. Delayed absorption weakens the potency of the medication while prolonging its effects. These effects might be unsafe because most heart medications have a narrow therapeutic index. Factors influencing the selection of alpha & beta blockers, nitrates, CCCBs, ACE-Is, diuretics, and digoxin will be reviewed.
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