新型天然除草剂3-吲哚甘氨酸衍生物的合成及植物毒性评价

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI:10.21577/0103-5053.20230058

A. Amaral, Julia Willig, C. Olguin, I. Oliveira, H. Stefani, G. Botteselle, F. Manarin

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引用次数: 0

摘要

摘要在水/十二烷基硫酸钠体系中，通过吲哚、醛和苯胺的多组分反应(za- friedel - crafts)，高效、绿色、快速地合成了一类具有潜在除草剂潜力的3-吲哚基甘氨酸。这种方法的主要优点是易于处理，可扩展到克尺度和无金属的方法。该反应与多种官能团相容，以中等至优异的产率获得所需的产物。对3-吲哚甘氨酸的生物活性进行了评价，发现这些化合物干扰了芥蓝的萌发和根的生长，主要是化合物4k。

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Synthesis and Phytotoxic Evaluation of 3-Indolylglycine Derivatives as New Natural-Like Herbicides

A novel class of potential herbicides, 3-indolylglycines were synthesized using an effective, green and rapid approach via multicomponent reaction (aza-Friedel-Crafts) between indoles, aldehydes and anilines in a water/sodium dodecyl sulfate system. The main advantages of this methodology are ease of handling, scalable to gram scale and a metal-free approach. The reaction is compatible with a variety of functional groups, obtaining the desired products in moderate to excellent yields. The biological activity of the 3-indolylglycines was evaluated, and it was found that these compounds interfere with the germination and radicle growth of Lactuca sativa, mainly the compound 4k.

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来源期刊

Journal of the Brazilian Chemical Society 化学-化学综合

CiteScore

2.90

自引率

7.10%

发文量

审稿时长

3.4 months

期刊介绍： The Journal of the Brazilian Chemical Society embraces all aspects of chemistry except education, philosophy and history of chemistry. It is a medium for reporting selected original and significant contributions to new chemical knowledge.