Masruroh Rahayu, S. Kurniawan, M. Husna, H. Hermawan
{"title":"酒酵母葡聚糖对鱼藤酮诱导的帕金森病WISTAR系大鼠黑质α -突触核蛋白表达降低的影响","authors":"Masruroh Rahayu, S. Kurniawan, M. Husna, H. Hermawan","doi":"10.21776/ub.mnj.2016.002.01.2","DOIUrl":null,"url":null,"abstract":"Background. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae. Objective. To identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats. Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group. Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinson’s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"24 1","pages":"9-13"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE DECREASE OF ALPHA SYNUCLEIN EXPRESSION IN THE BRAIN SUBSTANTIA NIGRA OF PARKINSON’S WISTAR STRAIN RATS (Rattus novergicus) MODEL INDUCED WITH ROTENONE\",\"authors\":\"Masruroh Rahayu, S. Kurniawan, M. Husna, H. Hermawan\",\"doi\":\"10.21776/ub.mnj.2016.002.01.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae. Objective. To identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats. Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group. Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinson’s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.\",\"PeriodicalId\":31552,\"journal\":{\"name\":\"Malang Neurology Journal\",\"volume\":\"24 1\",\"pages\":\"9-13\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Malang Neurology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21776/ub.mnj.2016.002.01.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Malang Neurology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21776/ub.mnj.2016.002.01.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE DECREASE OF ALPHA SYNUCLEIN EXPRESSION IN THE BRAIN SUBSTANTIA NIGRA OF PARKINSON’S WISTAR STRAIN RATS (Rattus novergicus) MODEL INDUCED WITH ROTENONE
Background. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae. Objective. To identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats. Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group. Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinson’s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.
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