植物源性乙酰胆碱酯酶抑制生物碱治疗阿尔茨海默病

S. Dall'acqua
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引用次数: 38

摘要

摘要:抑制乙酰胆碱酯酶(AChE)已成为治疗阿尔茨海默病(AD)最常用的策略之一。乙酰胆碱酯酶抑制剂(AChE- 1)不仅产生短期的症状效应,而且还可以在该疾病的其他病理机制中发挥作用(例如,淀粉样蛋白-β斑块的形成),这重新引起了人们对发现此类抑制剂的兴趣。目前针对阿尔茨海默病的五种处方治疗方法中有四种是疼痛- 1。天然生物碱如加兰他明或生物碱相关合成化合物(如利瓦斯汀)被认为对轻度至中度AD患者有益。然而,有必要发现更有效的化合物,因此,植物仍然可以成为新的乙酰胆碱- 1的潜在来源。本文综述了天然生物碱作为潜在的乙酰胆碱- 1新药的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease
Correspondence: Stefano Dall’Acqua Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5 35100, Padova, Italy Email stefano.dallacqua@unipd.it Abstract: The inhibition of acetylcholinesterase (AChE) has been one of the most used strategies for the treatment of Alzheimer’s disease (AD). The AChE inhibitors (AChE-I) produce not only short-term symptomatic effects, but can also play a role in other pathological mechanisms of the disease (eg, formation of amyloid-β plaques), which has renewed interest in the discovery of such inhibitors. Four of the five currently prescribed treatments for AD are AChE-I. Natural alkaloids such as galantamine or alkaloid-related synthetic compounds (such as rivastigmine) are considered beneficial for patients with mild-to-moderate AD. However, there is a need for the discovery of more effective compounds and for this reason, plants can still be a potential source of new AChE-I. Findings and advances in knowledge about natural alkaloids as potential new drugs acting as AChE-I will be summarized in this paper.
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