{"title":"植物源性乙酰胆碱酯酶抑制生物碱治疗阿尔茨海默病","authors":"S. Dall'acqua","doi":"10.2147/BTAT.S17297","DOIUrl":null,"url":null,"abstract":"Correspondence: Stefano Dall’Acqua Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5 35100, Padova, Italy Email stefano.dallacqua@unipd.it Abstract: The inhibition of acetylcholinesterase (AChE) has been one of the most used strategies for the treatment of Alzheimer’s disease (AD). The AChE inhibitors (AChE-I) produce not only short-term symptomatic effects, but can also play a role in other pathological mechanisms of the disease (eg, formation of amyloid-β plaques), which has renewed interest in the discovery of such inhibitors. Four of the five currently prescribed treatments for AD are AChE-I. Natural alkaloids such as galantamine or alkaloid-related synthetic compounds (such as rivastigmine) are considered beneficial for patients with mild-to-moderate AD. However, there is a need for the discovery of more effective compounds and for this reason, plants can still be a potential source of new AChE-I. Findings and advances in knowledge about natural alkaloids as potential new drugs acting as AChE-I will be summarized in this paper.","PeriodicalId":91458,"journal":{"name":"Botanics : targets and therapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2013-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/BTAT.S17297","citationCount":"38","resultStr":"{\"title\":\"Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease\",\"authors\":\"S. Dall'acqua\",\"doi\":\"10.2147/BTAT.S17297\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Correspondence: Stefano Dall’Acqua Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5 35100, Padova, Italy Email stefano.dallacqua@unipd.it Abstract: The inhibition of acetylcholinesterase (AChE) has been one of the most used strategies for the treatment of Alzheimer’s disease (AD). The AChE inhibitors (AChE-I) produce not only short-term symptomatic effects, but can also play a role in other pathological mechanisms of the disease (eg, formation of amyloid-β plaques), which has renewed interest in the discovery of such inhibitors. Four of the five currently prescribed treatments for AD are AChE-I. Natural alkaloids such as galantamine or alkaloid-related synthetic compounds (such as rivastigmine) are considered beneficial for patients with mild-to-moderate AD. However, there is a need for the discovery of more effective compounds and for this reason, plants can still be a potential source of new AChE-I. Findings and advances in knowledge about natural alkaloids as potential new drugs acting as AChE-I will be summarized in this paper.\",\"PeriodicalId\":91458,\"journal\":{\"name\":\"Botanics : targets and therapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-01-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2147/BTAT.S17297\",\"citationCount\":\"38\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Botanics : targets and therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/BTAT.S17297\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Botanics : targets and therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/BTAT.S17297","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease
Correspondence: Stefano Dall’Acqua Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5 35100, Padova, Italy Email stefano.dallacqua@unipd.it Abstract: The inhibition of acetylcholinesterase (AChE) has been one of the most used strategies for the treatment of Alzheimer’s disease (AD). The AChE inhibitors (AChE-I) produce not only short-term symptomatic effects, but can also play a role in other pathological mechanisms of the disease (eg, formation of amyloid-β plaques), which has renewed interest in the discovery of such inhibitors. Four of the five currently prescribed treatments for AD are AChE-I. Natural alkaloids such as galantamine or alkaloid-related synthetic compounds (such as rivastigmine) are considered beneficial for patients with mild-to-moderate AD. However, there is a need for the discovery of more effective compounds and for this reason, plants can still be a potential source of new AChE-I. Findings and advances in knowledge about natural alkaloids as potential new drugs acting as AChE-I will be summarized in this paper.