甲状腺髓样癌的初步手术治疗

IF 1.2

International Journal of Endocrine Oncology Pub Date : 2016-07-14 DOI:10.2217/IJE-2015-0009

Kathryn E. Coan, Tracy S. Wang

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引用次数: 0

摘要

甲状腺髓样癌(MTC)占甲状腺癌的5-10%。大多数MTC(75-80%)是散发性的，其余的是RET原癌基因突变的遗传性继发。遗传性甲状腺髓样癌可能与家族性甲状腺髓样癌分离，也可能与2A和2B型多发性内分泌瘤变综合征相关。散发性MTC的主要治疗方式是甲状腺全切除术和中央室颈清扫术;考虑侧颈剥离应基于术前影像学表现。预防性甲状腺切除术的时机取决于特定的RET密码子突变。

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Initial surgical management of medullary thyroid cancer

Medullary thyroid cancer (MTC) accounts for 5–10% of thyroid cancer. The majority, 75–80%, of MTC are sporadic with the remainder being hereditary secondary to a mutation in the RET proto-oncogene. Hereditary MTC may be isolated as in familial medullary thyroid cancer or associated with multiple endocrine neoplasia syndrome types 2A and 2B. The primary treatment modality for sporadic MTC is total thyroidectomy and central compartment neck dissection; consideration of lateral neck dissection should be based on preoperative imaging findings. The timing of prophylactic thyroidectomy is dependent on the specific RET codon mutation.

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来源期刊

International Journal of Endocrine Oncology ONCOLOGY-

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Endocrine Oncology is a quarterly, peer-reviewed journal that helps the clinician to keep up to date with best practice in this fast-moving field. The journal highlights significant advances in basic and translational research, and places them in context for future therapy. The journal presents the latest research findings in diagnosis and management of endocrine cancer, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. The journal welcomes the unsolicited submission of article proposals and original research manuscripts.