细针穿刺非典型性/滤泡性病变甲状腺结节的评价与处理

IF 1.2
I. Bobanga, C. McHenry
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引用次数: 0

摘要

自2008年引入Bethesda甲状腺细胞病理学报告系统以来,甲状腺结节的管理变得更加标准化,并根据六种细胞学类别中的每一种的恶性风险明确定义了算法。然而,细针穿刺活检分类为Bethesda III或不确定意义的异型性/不确定意义的滤泡性病变(AUS/FLUS)的甲状腺结节的处理仍然存在争议,因为细胞学的异质性和报告的恶性肿瘤率的可变性。在这篇综述中,研究了新的Bethesda III分类的历史和基本原理,回顾了已发表的研究中报道的恶性肿瘤的发病率和风险,并提供了甲状腺结节和AUS/FLUS患者的治疗建议。本文还讨论了分子分析的最新进展及其在评价AUS/FLUS患者中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation and management of thyroid nodules with atypia/follicular lesion of undetermined significance on fine-needle aspiration
Since the introduction of the Bethesda System for Reporting Thyroid Cytopathology in 2008, the management of thyroid nodules has become more standardized, with clearly defined algorithms based on risk of malignancy for each of the six cytologic categories. However, the management of a thyroid nodule with a fine-needle aspiration biopsy classified as Bethesda III, or atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS), remains controversial due to the cytologic heterogeneity and the variability in the reported rates of malignancy. In this review, the history and rationale for the new Bethesda III category is examined, the reported incidence and risk of malignancy from published studies is reviewed and recommendations for management of patients with a thyroid nodule and AUS/FLUS are provided. Recent advances in molecular analysis and their role in the evaluation of patients with AUS/FLUS are also discussed.
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来源期刊
自引率
0.00%
发文量
0
审稿时长
13 weeks
期刊介绍: International Journal of Endocrine Oncology is a quarterly, peer-reviewed journal that helps the clinician to keep up to date with best practice in this fast-moving field. The journal highlights significant advances in basic and translational research, and places them in context for future therapy. The journal presents the latest research findings in diagnosis and management of endocrine cancer, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. The journal welcomes the unsolicited submission of article proposals and original research manuscripts.
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