超脉冲动态CO2激光和超分子水杨酸联合治疗短时间内清除率较高的致密性粉刺：一项前瞻性、随机、分面临床试验

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2023-08-15 DOI:10.1002/lsm.23717

Meng-yao Yang MB, Jing Liu PhD, Di-chao Ning PhD, Yan-ting Liu PhD, Dan Ye MB, Chen Tu PhD, Zhao Wang MD, PhD, Wei-Hui Zeng MD

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引用次数: 1

摘要

目的致密性粉刺在寻常痤疮患者中很常见，促进治疗可以防止痤疮病变的进展。然而，疗效-时间冲突使治疗具有挑战性，药物选择也受到副作用的限制。材料和方法35例对称性致密粉刺患者被随机分配到面部两侧，接受30%超分子水杨酸（SSA）联合CO2激光或CO2激光单药治疗，间隔2周，共6个疗程。在每次就诊至第12周时记录喜剧演员计数、卟啉指数（PI）、质地指数（TI）、黑色素指数、红斑指数、水合指数（HI）、经表皮失水（TEWL）和副作用。结果31例患者完成了研究。经6次治疗后，SSA联合侧的喜剧演员减少较多，SSA综合侧的平均减少率为85.76%，CO2激光治疗侧的平均降低率为62.32%（P <； 0.001）。联合SSA也显示出比单独CO2激光更好的降低PI和TI的效果（P <； 0.001）。治疗后两组间TEWL和HI无明显差异。两侧均未观察到永久性或严重的副作用。结论CO2激光联合30%SSA治疗在12周内有效地解决了疗效时间冲突，同时显著减少了粉刺，改善了皮肤纹理，没有发生严重的不良反应。局限性这是一项单中心研究，受试者数量很少。

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Combining superpulse dynamic CO2 laser and supramolecular salicylic acid in the treatment of dense comedones with higher clearance in a shorter time: A prospective, randomized, split-face clinical trial

Objectives

Dense comedones are common in patients with acne vulgaris, and promoting treatment can prevent the progression of acne lesions. However, the efficacy-time conflict makes the treatment challenging and the medication options are limited by the side effects.

Materials and methods

Thirty-five patients with symmetrical dense comedones were enrolled and the two sides of the face were randomly assigned to receive 30% supramolecular salicylic acid (SSA) combined with CO₂ laser or CO₂ laser monotherapy at an interval of 2 weeks for six treatment sessions. Comedones count, porphyrin index (PI), texture index (TI), melanin index, erythema index, hydration index (HI), transepidermal water loss (TEWL), and side effects were recorded at each visit till the 12th week.

Results

Thirty-one patients completed the study. Comedones on the combined-SSA side were reduced more after six treatments, that the mean reduction rate of the combined-SSA side was 85.76%, and that of the CO₂ laser-treated side was 62.32% (P_between < 0.001). Combining SSA also showed a better effect on reducing PI and TI than CO₂ laser singly (P_between < 0.001). TEWL and HI between the two sides showed no significant differences after treatments. No permanent or severe side effects were observed on both side.

Conclusions

The treatment combined CO₂ laser with 30% SSA dealt with the efficacy-time conflict while significantly reducing comedones and improving skin texture in 12 weeks and no serious adverse reactions occurred.

Limitations

It is a single-center study and the number of subjects was small.

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.