浸润性乳腺癌中MAGE-1癌睾丸抗原表达的评价及其与预后因素的相关性

Mojtaba Rastgoosalami, B. Memar, S. Aledavood, A. Fanipakdel
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引用次数: 8

摘要

肿瘤睾丸抗原(CTA)在乳腺癌组织中的异常表达及其在远离免疫系统的睾丸组织中的自然表达,使其成为癌症免疫治疗和疫苗设计的良好候选者。目的本研究的目的是评估CTA (MAGE-1)在浸润性乳腺癌中的表达及其与预后因素的相关性。方法采用免疫组化(IHC)方法对2011 - 2013年113例乳腺癌患者的组织石蜡块进行mage -1表达染色。使用SPSS 16进行统计分析,评估MAGE-1表达与已知预后因素的相关性。结果30.1%的患者癌细胞细胞质中存在不同程度的MAGE-1表达,其中中度表达23.9%,强烈表达6.2%。核染色变为阳性的占31.8%,从中度(26.5%)到强烈(5.3%)分层。淋巴结受累数与细胞核(P = 0.042)和细胞质(P = 0.003) MAGE-1表达均有显著相关性。MAGE-1的核表达与肿瘤大小也有显著相关性(P = 0.018)。MAGE-1的细胞质表达随肿瘤病理分级的增加而增加,但相关性无统计学意义(P = 0.119)。结论CTA MAGE-1与乳腺癌的一些预后因素有显著相关性,可能具有预后因素的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of MAGE-1 Cancer-Testis Antigen Expression in Invasive Breast Cancer and its Correlation with Prognostic Factors
Background Aberrant expression of cancer-testis antigens (CTA) in breast carcinoma tissue, and its natural expression in the testis, the tissue away from the immune system, makes them good candidates for cancer immunotherapy and vaccines designing. Objectives The aim of this study was to assess the expression of a CTA (MAGE-1) in invasive breast cancer and its correlation with prognostic factors. Methods Paraffin blocks of breast cancer tissues from 113 patients operated in 2011 - 2013 were stained for MAGE-1expression by immunohistochemistry (IHC). The associations of MAGE-1 expression with known prognostic factors were assessed by statistical analysis using SPSS 16. Results MAGE-1 expression was found in cancer cell cytoplasms of 30.1% of patients, with different degrees of intensity, (23.9% moderate and 6.2% strong). Nuclear staining turned positive in 31.8%, stratified from moderate in 26.5%to to strong in 5.3%. There was a significant association between the number of lymph nodes involved and both nuclear (P = 0.042) and cytoplasmic (P = 0.003) MAGE-1 expression. There was also a significant correlation between the nuclear expression of MAGE-1 and tumor size (P = 0.018). Cytoplasmic expression of MAGE-1 increased with increasing pathologic grade of tumors although the association was not statistically significant (P = 0.119). Conclusions CTA MAGE-1 has significant association with some prognostic factors in breast cancer and may have the role of a prognostic factor.
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