{"title":"GH/ igf -1轴在精神病理功能中的作用","authors":"M. Auer, C. Sievers, H. Schneider, G. Stalla","doi":"10.2174/1874216501206010062","DOIUrl":null,"url":null,"abstract":"Alterations of the somatotropic system as seen in Growth Hormone Deficiency (GHD) or acromegaly can lead to a variety of mental and physical impairments. Especially the prevalence of psychiatric disorders is elevated and cognitive function is impaired. These changes are paralleled by disturbances of the macroscopic brain tissue architecture and may persist despite achievement of biochemical control. On the other hand strong alterations in GH-secretion and impaired regulatory response to exogenous stimulation have been described in a variety of studies investigating the somatotropic feedback-loop in mood disorders. This reciprocal relationship indicates certain effects of this hormone system in the modulation of neuronal function and an involvement in the pathogenesis of psychiatric disorders.","PeriodicalId":88751,"journal":{"name":"The open endocrinology journal","volume":"6 1","pages":"62-67"},"PeriodicalIF":0.0000,"publicationDate":"2012-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"The GH/IGF-1-Axis in Psychopathological Functions\",\"authors\":\"M. Auer, C. Sievers, H. Schneider, G. Stalla\",\"doi\":\"10.2174/1874216501206010062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alterations of the somatotropic system as seen in Growth Hormone Deficiency (GHD) or acromegaly can lead to a variety of mental and physical impairments. Especially the prevalence of psychiatric disorders is elevated and cognitive function is impaired. These changes are paralleled by disturbances of the macroscopic brain tissue architecture and may persist despite achievement of biochemical control. On the other hand strong alterations in GH-secretion and impaired regulatory response to exogenous stimulation have been described in a variety of studies investigating the somatotropic feedback-loop in mood disorders. This reciprocal relationship indicates certain effects of this hormone system in the modulation of neuronal function and an involvement in the pathogenesis of psychiatric disorders.\",\"PeriodicalId\":88751,\"journal\":{\"name\":\"The open endocrinology journal\",\"volume\":\"6 1\",\"pages\":\"62-67\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The open endocrinology journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874216501206010062\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open endocrinology journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874216501206010062","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Alterations of the somatotropic system as seen in Growth Hormone Deficiency (GHD) or acromegaly can lead to a variety of mental and physical impairments. Especially the prevalence of psychiatric disorders is elevated and cognitive function is impaired. These changes are paralleled by disturbances of the macroscopic brain tissue architecture and may persist despite achievement of biochemical control. On the other hand strong alterations in GH-secretion and impaired regulatory response to exogenous stimulation have been described in a variety of studies investigating the somatotropic feedback-loop in mood disorders. This reciprocal relationship indicates certain effects of this hormone system in the modulation of neuronal function and an involvement in the pathogenesis of psychiatric disorders.
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