Hybolites再访。

Q3 Medicine

Recent patents on anti-infective drug discovery Pub Date : 2016-01-01 DOI:10.2174/1574891x11666160406121706

V. Norris, Cécile Verrier, M. Feuilloley

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引用次数: 2

摘要

超结构是分子和大分子的大型集合，具有代谢(包括RNA和蛋白质的合成和降解)、运输、DNA复制、细胞分裂、信号传导和趋化等功能。方法这种超结构可能是由杂交代谢物或由数千个参与代谢和信号传导的小分子的成对共价连接组合而成的半代谢物操纵的。在这里，我们回顾了最近的证据表明，在原核生物的超结构和超结构之间的相互作用作为表型的决定因素。我们还提到将双糖疗法扩展到真核生物，考虑双糖的新设计，并讨论相关专利。

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Hybolites Revisited.

BACKGROUND Hyperstructures are large assemblies of molecules and macromolecules that perform functions such as metabolism (including RNA and protein synthesis and degradation), transport, DNA replication, cell division, signalling and chemotaxis. METHODS Such hyperstructures might be manipulated by hybrid metabolites or hybolites made by a pairwise, covalently linked combination of the thousands of small molecules involved in metabolism and signalling. RESULTS Here, we review recent evidence for hyperstructures in prokaryotes and for interactions between hyperstructures as a determinant of the phenotype. We also mention extending hybolite therapy to eukaryotes, consider new designs for hybolites, and discuss relevant patents.

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来源期刊

Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.