{"title":"乳酸作为聚丙烯酸与4-氨基安替比林之间的间隔剂","authors":"Fiyral Mohammad Ali, T. AL-Noor, Saif Mohsin Ali","doi":"10.18488/JOURNAL.57/2015.4.6/57.6.36.45","DOIUrl":null,"url":null,"abstract":"Due to many problems associated with drug release and side effects, we could design a novel drug delivery system through modification of poly acrylic acid (AA) with Lactic acid as a spacer between the polymer and 4-aminoantipyrine. In vitro drug release had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37?. The prepared prodrug polymer was characterized by FTIR and 1H?NMR spectra. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Lactic Acid as Spacer between Poly Acrylic Acid and 4-Aminoantipyrine\",\"authors\":\"Fiyral Mohammad Ali, T. AL-Noor, Saif Mohsin Ali\",\"doi\":\"10.18488/JOURNAL.57/2015.4.6/57.6.36.45\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Due to many problems associated with drug release and side effects, we could design a novel drug delivery system through modification of poly acrylic acid (AA) with Lactic acid as a spacer between the polymer and 4-aminoantipyrine. In vitro drug release had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37?. The prepared prodrug polymer was characterized by FTIR and 1H?NMR spectra. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.\",\"PeriodicalId\":91506,\"journal\":{\"name\":\"International journal of biotechnology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18488/JOURNAL.57/2015.4.6/57.6.36.45\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18488/JOURNAL.57/2015.4.6/57.6.36.45","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Lactic Acid as Spacer between Poly Acrylic Acid and 4-Aminoantipyrine
Due to many problems associated with drug release and side effects, we could design a novel drug delivery system through modification of poly acrylic acid (AA) with Lactic acid as a spacer between the polymer and 4-aminoantipyrine. In vitro drug release had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37?. The prepared prodrug polymer was characterized by FTIR and 1H?NMR spectra. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.
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