健康人先天免疫细胞在21天干浸泡期间的免疫调节剂敏感性

Q4 Biochemistry, Genetics and Molecular Biology
A. Gornostaeva, L. Buravkova
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引用次数: 0

摘要

在正常受试者的参与下,研究了自然杀伤细胞(NK)对多能间充质基质细胞(MSCs)免疫抑制作用的敏感性。DI影响NK对IL-2和IL-15刺激的敏感性,激活标记物HLA-DR、CD314和CD226的表达,总旁分泌活性以及关键抗炎介质如MIP-1b、MIP-1a、RANTES、IL-1a、IL-1b等的产生。在DI之前,MSCs对NK的作用表现为抑制晚期激活。注射后,MSCs的作用减弱;然而,与MSCs的相互作用通过刺激细胞因子分泌来消除DI对旁分泌活性的影响。因此,DI降低了NK对激活刺激和MSCs的敏感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
IMMUNOMODULATOR SENSITIVITY OF INNATEIMMUNITY CELLS IN HEALTHY HUMAN SUBJECTS DURING 21-DAY DRY IMMERSION
Sensitivity of natural killers (NK) to the immunosuppressive effect of multipotent mesenchymal stromal cells (MSCs) was investigated in vitroa 21-d dry immersion (DI) study with participation of normal human subjects. DI affected the NK sensitivity to IL-2 and IL-15 stimulation, expression of activating markers HLA-DR, CD314 and CD226, total paracrine activity and production of key anti-inflammatory mediators such as MIP-1b, MIP-1a, RANTES, IL-1a, IL-1b, etc. Prior to DI, the MSCs action on NK showed itself as suppression of late activation. During DI, the MSCs effects grew weak; however, interaction with MSCs smoothed out DI influence on the paracrine activity by stimulation of cytokines secretion. Therefore, DI decreased the NK sensitivity both to the activating stimuli and MSCs.
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来源期刊
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
0.60
自引率
0.00%
发文量
36
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