{"title":"药物b-190(吲哚林)耐受性;它对飞行员职业活动和抵抗极端飞行因素的影响","authors":"L. Ilyin, M. V. Vasin, I. Ushakov","doi":"10.21687/0233-528x-2022-56-4-27-34","DOIUrl":null,"url":null,"abstract":"We undertook analysis of testing tolerance to fast-acting radioprotector B-190 (indralin) by 147 pilots and test-subjects in a number of simulators. Indralin, a direct 1(В)-adrenergic vasopressor, increases peripheral resistance and controls local blood flow. As a result, diastolic and systolic pressure grows and heart rate decreases reflectively for a period of up to an hour. Indralin did not impact endurance of head-to-pelvis g-loading (+5 g, 30 s), hypobaric hypoxia (5 000 m, 30 min), vestibular stimulation (continuous cumulative Coriolis effect), hyperthermia (+35 °С and 55 % relative humidity) and 1-hour physical work at 50 watts in a protective marine outfit and sealed respirator mask. Indralin did not affect physical endurance or performance assessed by functioning of the neuromotor apparatus (dynamic work, static stability, resting and motion tremor, sensorimotor reaction). Investigations of the indralin effects on operator's psychophysiology and efficiency in a flight simulator showed that it did not act dramatically on job quality and attention, visual or motor functions and that operator's self-appraisal remained adequate.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TOLERANCE OF MEDICAMENT B-190 (INDRALIN); ITS EFFECT ON PILOT'S PROFESSIONAL ACTIVITIES AND RESISTANCE TO EXTREME FLIGHT FACTORS\",\"authors\":\"L. Ilyin, M. V. Vasin, I. Ushakov\",\"doi\":\"10.21687/0233-528x-2022-56-4-27-34\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We undertook analysis of testing tolerance to fast-acting radioprotector B-190 (indralin) by 147 pilots and test-subjects in a number of simulators. Indralin, a direct 1(В)-adrenergic vasopressor, increases peripheral resistance and controls local blood flow. As a result, diastolic and systolic pressure grows and heart rate decreases reflectively for a period of up to an hour. Indralin did not impact endurance of head-to-pelvis g-loading (+5 g, 30 s), hypobaric hypoxia (5 000 m, 30 min), vestibular stimulation (continuous cumulative Coriolis effect), hyperthermia (+35 °С and 55 % relative humidity) and 1-hour physical work at 50 watts in a protective marine outfit and sealed respirator mask. Indralin did not affect physical endurance or performance assessed by functioning of the neuromotor apparatus (dynamic work, static stability, resting and motion tremor, sensorimotor reaction). Investigations of the indralin effects on operator's psychophysiology and efficiency in a flight simulator showed that it did not act dramatically on job quality and attention, visual or motor functions and that operator's self-appraisal remained adequate.\",\"PeriodicalId\":8683,\"journal\":{\"name\":\"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21687/0233-528x-2022-56-4-27-34\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21687/0233-528x-2022-56-4-27-34","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
摘要
我们对147名飞行员和测试对象在多个模拟器中对速效无线电保护器B-190 (indralin)的测试耐受性进行了分析。Indralin是一种直接的(В)-肾上腺素能血管加压素,可增加外周阻力并控制局部血流。结果,舒张压和收缩压增加,心率反射性下降长达一个小时。Indralin不影响头部到骨盆的g负荷(+5 g, 30 s)、低气压缺氧(5 000 m, 30 min)、前庭刺激(持续累积科里奥利效应)、高温(+35°С和55%相对湿度)和50瓦下穿着海洋防护服和密封呼吸器面罩进行1小时体力工作的耐力。因德拉林不影响身体耐力或通过神经运动器官功能评估的表现(动态工作、静态稳定性、休息和运动震颤、感觉运动反应)。在飞行模拟器中对操作员心理生理和效率的内在影响的调查表明,它对工作质量和注意力、视觉或运动功能没有显着作用,并且操作员的自我评价仍然足够。
TOLERANCE OF MEDICAMENT B-190 (INDRALIN); ITS EFFECT ON PILOT'S PROFESSIONAL ACTIVITIES AND RESISTANCE TO EXTREME FLIGHT FACTORS
We undertook analysis of testing tolerance to fast-acting radioprotector B-190 (indralin) by 147 pilots and test-subjects in a number of simulators. Indralin, a direct 1(В)-adrenergic vasopressor, increases peripheral resistance and controls local blood flow. As a result, diastolic and systolic pressure grows and heart rate decreases reflectively for a period of up to an hour. Indralin did not impact endurance of head-to-pelvis g-loading (+5 g, 30 s), hypobaric hypoxia (5 000 m, 30 min), vestibular stimulation (continuous cumulative Coriolis effect), hyperthermia (+35 °С and 55 % relative humidity) and 1-hour physical work at 50 watts in a protective marine outfit and sealed respirator mask. Indralin did not affect physical endurance or performance assessed by functioning of the neuromotor apparatus (dynamic work, static stability, resting and motion tremor, sensorimotor reaction). Investigations of the indralin effects on operator's psychophysiology and efficiency in a flight simulator showed that it did not act dramatically on job quality and attention, visual or motor functions and that operator's self-appraisal remained adequate.