第四型心肌梗死:经皮冠状动脉后的流动、预防和治疗

Наталья Григорьевна Правдюк, Анна Владимировна Новикова, Елена Анатольевна Королева
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引用次数: 2

摘要

迄今为止,心血管疾病在许多国家的总发病率和死亡率结构中占据首位。2013年在俄罗斯联邦死于心血管疾病的179.9万人中,来自底层的529.8万人死于冠心病,主要作用属于心肌梗死及其并发症。目前,诊断冠心病(包括心肌梗死)的“金标准”仍然是冠状动脉造影;冠状动脉造影的主要目的是评估冠状动脉的解剖特征,确定血管内治疗心肌梗死的可能性,并通过支架植入术重建血管。尽管技术不断进步,在药物支持方面也取得了进步,但经皮冠状动脉介入治疗(PCI)是一种有创操作,存在一定的风险。4a型心肌梗死的诊断标准包括PCI术后48小时内肌钙蛋白水平升高5条规则第99条上阈值参考值以上,正常肌钙蛋白升高(≤第99条上阈值参考值),或初始高水平肌钙蛋白患者肌钙蛋白水平≥20%并伴有心肌缺血延长的证据。支架在进行经皮冠状动脉介入治疗时,伴随着血栓形成反应的激活,可导致血栓形成而发展为4b型。4b型心肌梗死的诊断征象是支架内血栓形成,经血管造影证实和/或尸检证实,并结合肌钙蛋白水平升高至少大于第99个上阈值的参考值。支架置入PCI时,伴血栓形成反应的激活,可导致血栓形成,发展为4b型心肌梗死。4b型心肌梗死的诊断征象是支架内血栓形成,经血管造影证实和/或尸检证实,并合并肌钙蛋白水平升高,至少大于第99个上阈值的参考值。你应该考虑这样一个事实:药物洗脱支架的设置增加了植入后内皮化的时间,这反过来又增加了晚期血栓形成的可能性,这是长期双重抗血小板治疗的适应症。本文描述了与PCI相关的各种心肌梗死,PCI是一种根据当前临床建议诊断和管理患者的算法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ИНФАРКТ МИОКАРДА 4-ГО ТИПА: ОСОБЕННОСТИ ТЕЧЕНИЯ, ПРОФИЛАКТИКА И ВЕДЕНИЕ БОЛЬНЫХ ПОСЛЕ ЧРЕСКОЖНЫХ КОРОНАРНЫХ ВМЕШАТЕЛЬСТВ
To date, cardiovascular diseases occupy the first place in the structure of total morbidity and mortality in many countries. In 2013 in the Russian Federation from cardiovascular disease died 1 million 799 thousand people, from the bottom 529.8 thousand from coronary heart disease, the primary role belongs to myocardial infarction and its complications. Currently, the "gold standard" for the diagnosis of coronary heart disease, including myocardial infarction, remains coronary angiography; the main objectives of coronary angiography are to assess the features of the coronary anatomy, determination of the possibility of endovascular treatment of myocardial infarction and revascularization by stent implantation. Despite the constant improvement of technology and the progress made in relation to pharmacological support, percutaneous coronary intervention (PCI) is an invasive manipulation, which is associated with a certain risk. Diagnostic criteria for myocardial infarction 4a type include increasing the level of troponin above 5 rules of 99th the upper threshold reference values within 48 hours after the PCI procedure, in patients with normal troponin increased (≤ 99th the upper threshold reference values), or a level of troponin 20 % or more in patients with initial high level troponin combined with evidence of prolonged myocardial ischemia. Stent when performing percutaneous coronary interventions, accompanied by the activation of thrombogenic reactions, can lead to thrombosis and development 4b type. To the diagnostic signs of the myocardial infarction 4b type are the stent thrombosis, angiographic proven and/or at autopsy, in combination with increased troponin level at least one greater than the 99th the upper threshold reference values. Stent when performing PCI, accompanied by the activation of thrombogenic reactions, can lead to thrombosis and development myocardial infarction 4b type. The diagnostic signs myocardial infarction 4b type are the stent thrombosis, angiographic proven and/or at autopsy, in combination with increased troponin level at least one greater than the 99th the upper threshold reference values. You should consider the fact that the setting of drug-eluting stents increases the period of their endothelization after implantation, which in turn increases the likelihood of late thrombosis and is an indication for long-term dual antiplatelet therapy. The article describes the varieties of myocardial infarction associated with PCI, an algorithm for the diagnosis and management of patients in accordance with current clinical recommendations.
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