口服和鼻腔疫苗接种:目前的前景、挑战和基于纳米技术的递送系统的影响

Pub Date : 2023-05-08 DOI:10.1590/s2175-97902023e21769

Natália Floriano Paiva, F. Vicentini

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引用次数: 0

摘要

目前，粘膜疫苗给药作为一种较为简便、无创的应用方法而备受关注。它也可用于诱导局部和全身免疫反应。在COVID-19大流行背景下，基于不同的技术平台开发了鼻用和口服疫苗。这篇综述讨论了粘膜疫苗给药的相关方面，重点是口服和鼻腔疫苗接种，以及使用基于纳米技术的递送系统来实现这些策略的重要性。

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Oral and nasal vaccination: current prospects, challenges, and impact of nanotechnology-based delivery systems

Abstract Currently, mucosal vaccine administration has stood out as an easier and non-invasive application method. It can also be used to induce local and systemic immune responses. In the COVID-19 pandemic context, nasal and oral vaccines have been developed based on different technological platforms. This review addressed relevant aspects of mucosal vaccine administration, with emphasis on oral and nasal vaccinations, in addition to the importance of using nanotechnology-based delivery systems to enable these strategies.

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