肺炎链球菌的种特异性抗原作为新诊断系统的前景

Q4 Medicine

Infektsionnye Bolezni Pub Date : 2021-01-01 DOI:10.20953/1729-9225-2021-4-73-78

N. G. Sidorov, A. Poddubikov

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引用次数: 0

摘要

肺炎链球菌引起的感染一直是全球卫生保健面临的重大挑战。现有的诊断方法并不总是能够识别无胶囊形式的肺炎球菌或耐光素菌株，这些菌株在肺炎球菌感染的发展中也起着重要作用。诊断程序的这种局限性要求开发与血清型无关的检测方法。本文综述了肺炎链球菌的抗原结构、壁壁酸和脂壁壁酸的特异性，并对目前可用的诊断方法进行了分析。我们评估了物种特异性抗原作为新诊断系统候选物的效用。关键词:肺炎链球菌，磷壁酸，脂磷壁酸，胆碱结合蛋白，种特异性抗原

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Species-specific antigens of Streptococcus pneumoniae as an outlook for new diagnostic systems

Infections caused by Streptococcus pneumoniae have always been a significant challenge for healthcare worldwide. Existing diagnostic methods are not always able to identify capsule-free forms of pneumococci or optochin-resistant strains that also play an important role in the development of pneumococcal infections. Such limitations of diagnostic procedures necessitate the development of serotype-independent tests. This review focuses on the antigenic structure of Streptococcus pneumoniae, specific characteristics of teichoic and lipoteichoic acids, and analyzes currently available diagnostic methods. We evaluated the utility of species-specific antigens as candidates for new diagnostic systems. Key words: Streptococcus pneumoniae, teichoic acid, lipoteichoic acid, choline binding proteins, species-specific antigens

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来源期刊

Infektsionnye Bolezni Medicine-Infectious Diseases

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.