免疫代谢:免疫介导疾病治疗的新视角

Q3 Medicine

Voprosy Detskoi Dietologii Pub Date : 2022-01-01 DOI:10.20953/1727-5784-2022-1-52-57

O. Netrebenko, P. Shumilov

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引用次数: 0

摘要

免疫系统和新陈代谢之间的密切联系已经在许多实验和临床研究中被确定。免疫系统的细胞由于活跃的增殖，对能量的需求是最高的，而它们没有储存能量的仓库和塑料，依赖于从外部摄取。免疫细胞的表型和功能活性直接取决于其能量供应的类型。营养过剩或营养不良、某些微量营养素缺乏和肠道代谢活动显著影响免疫细胞功能。基本代谢和信号通路的调节对T细胞的增殖、分化和功能活性有相当大的影响。免疫细胞代谢靶向治疗是一种很有前途的治疗免疫介导性疾病和癌症的方法。关键词:免疫代谢，代谢，T细胞，炎症，癌症，治疗

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Immunometabolism: new perspectives for the treatment of immune-mediated diseases

A close connection between the immune system and metabolism has been identified in many experimental and clinical studies. The cells of the immune system have the highest energy requirements due to active proliferation, while they have no depot of energy storage and plastics and depend on their ingestion from outside. The phenotype and functional activity of immune cells directly depend on the type of their energy supply. Overnutrition or malnutrition, deficiency of certain micronutrients, and intestinal metabolic activity significantly affect immune cell function. Modulation of basic metabolic and signaling pathways has a considerable impact on the proliferation, differentiation, and functional activity of T cells. Metabolic targeted therapy for immune cells is a promising type of treatment for immune-mediated and cancer diseases. Key words: immunometabolism, metabolism, T cells, inflammation, cancer, treatment

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来源期刊

Voprosy Detskoi Dietologii Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： The scientific journal Voprosy Detskoi Dietologii is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Food Science, Pediatrics, Perinatology, and Child Health, Nutrition and Dietetics, Клиническая медицина.