通过注射卵泡刺激激素来模拟功能卵巢囊肿

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Daria A. Trus, O. A. Tikhonovskaya, A. Okorokov, Liliya R. Mustafina, O. S. Timofeeva, S. V. Logvinov, A. V. Gerasimov, Elena Yu. Varakuta, Aleksey V. Potapov, G. A. Suhanova, Irina G. Kutsenko
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引用次数: 0

摘要

的目标。目的:研究重组卵泡刺激素对卵巢形态功能的影响。材料和方法。实验采用两组成熟雌性Wistar大鼠。实验组35只大鼠建立卵泡性卵巢囊肿模型,对照组25只大鼠。大鼠于第3、7、15、30、60天退出实验。用Van Gieson染色法对卵巢石蜡切片进行苏木精和伊红染色。进行组织学和形态计量学调查。结果。在FSH给药的第7天,由于单细胞卵泡囊肿的形成,卵巢的大小增加最大。实验组大鼠在第7天和第15天的生长卵泡数量明显减少。在第7天观察到闭锁体和卵泡数量较对照组增加,并持续到试验结束。实验第7天,大鼠充血、血管收缩。实验期间黄体数量减少,从实验第15天开始胶原蛋白形成增加。结论。引入促卵泡激素7天,导致卵泡发生中断,卵巢闭锁加强,形成功能性囊肿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Моделирование функциональных кист яичников путем введения фолликулостимулирующего гормона
Aim. To study the morphofunctional state of ovaries after the introduction of recombinant FSH. Materials and methods. Two groups of mature female Wistar rats were used in the study. The experimental group consisted of 35 rats with a model of follicular ovarian cysts, while 25 rats were in the control group. Rats were taken out of the experiment on days 3, 7, 15, 30 and 60. Paraffin slides of ovaries were stained with hematoxylin and eosin by Van Gieson. Histological and morphometric investigations were performed. Results. On day 7 of FSH administration, the maximum increase in the size of the ovaries was observed due to the formation of single-cell follicular cysts. Rats in the experimental group showed a marked decrease in the number of growing follicles on day 7 and 15. The increase in atretic bodies and follicles in comparison with the control group was observed on day 7 and lasted until the end of the experiment. Additionally, on day 7 of the experiment, hyperemia and vasoconstriction were noted. The number of yellow bodies decreased during the experiment, and an increase in collagen formation occurred starting from day 15 of the experiment. Conclusion. The introduction of follicle-stimulating hormone for 7 days leads to disruption of folliculogenesis, strengthening of atresia in the ovaries, and the formation of functional cysts.
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来源期刊
Byulleten Sibirskoy Meditsiny
Byulleten Sibirskoy Meditsiny MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
50.00%
发文量
102
审稿时长
8 weeks
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