耐力运动训练对实验性心肌梗死大鼠心肌组织形态学变化的影响

A. A. Jazi, Hadi Abdi, Mohammad Reza Hafezi Ahmadi, J. Cheraghi
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引用次数: 8

摘要

心肌梗死后的心脏重构与进行性心室功能障碍和心血管死亡相关。本研究旨在探讨耐力运动训练对实验性心肌梗死后大鼠心脏组织形态学变化的影响。材料与方法:实验用大鼠(8-10周龄,体重235±5 g)均质后,按体重随机分为健康组(Sham)、对照组(久坐)和耐力训练组。连续2天皮下注射异丙肾上腺素(150 mg/kg),间隔24小时诱导心肌梗死。梗塞后2天开始耐力训练,持续4周。分别采用苏木精-伊红染色和马松三色染色评价坏死灶和纤维化组织。资料分析采用单因素方差分析(ANOVA), P< 0.05。结果:皮下注射异丙肾上腺素可诱导大鼠心肌梗死。耐力训练组的坏死性病变发生率显著高于久坐(对照组)(P=0.005)。同时,耐力训练组纤维化组织的大小明显高于久坐(对照组)组(P= 0.001)。结论:总的来说,本研究结果表明心肌梗死后4周的耐力运动训练加重了大鼠心脏组织损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction
Introduction: Cardiac remodeling after myocardial infarction, is associated with progressive ventricular dysfunction and cardiovascular death. The purpose of this study was to examine the effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction. Materials and methods: Rats used in this experiment (8-10 weeks old, 235 ± 5 g body weight) after homogenization according to body weight, were randomly divided to three groups: Healthy (Sham), control (Sedentary) and endurance training groups. Myocardial infarction was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days with an interval of 24 hours. Endurance training initiated 2 days after infarction and continued for 4 weeks. In order to assess the necrosis lesion and fibrosis tissue, Hematoxylin–Eosin and Masson's trichrome staining were used, respectively. Data were analyzed by using one-way analysis of variance (ANOVA) at P< 0.05 level. Results: The results indicated that subcutaneous injection of isoprenaline, induced myocardial infarction in rat heart tissue. Rate of necrotic lesion in the Endurance training group was significantly higher than Sedentary (control) group (P=0.005). Also, the size of fibrosis tissue in the Endurance training group was significantly higher than the sedentary (control) group (P= 0.001). Conclusion: In general, results of this study showed that 4 weeks of endurance exercise training after myocardial infarction exacerbate tissue injury in rat heart.
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