{"title":"苯并吡喃(铬酮类)和苯并呋喃酮(香豆素类)衍生物对斯坦奈菌的活性研究","authors":"K. Khairan, M. Bahi, C. Jacob, R. Idroes","doi":"10.21157/J.KED.HEWAN.V10I1.3368","DOIUrl":null,"url":null,"abstract":"This study was purposed to inquire the activities of benzopyran (chromones) and benzofuranones (coumaranones) derivatives against Steinernema feltiae (S. feltiae). The toxicity assay against S. feltiae showed that benzopyran derivatives 2, 3, 4, 6, and 9 have the highest activity on S. feltiae with viabilities percentage of <50%. The compound 9 demostrated the highest activity with LD 50 and LD values, 7.2 and 52.2 μM, respectively. The activities of compound 7 and 10 showed the lowest toxicity. Interestingly, the activity of benzofuranone derivatives showed significant activities against S. feltiae. Compare to benzopyran derivatives, the benzofuranone derivatives has the highest toxicity, in particular compound 13 with LD 5.45 μM. The nematicidal assay showed that benzofuranones (coumaranones) derivatives revealed higher activities than benzopyran (chromones) derivatives. Key words: chromones, benzopyran, coumaranones, benzofuranone, and Steinernema feltiae","PeriodicalId":30999,"journal":{"name":"Jurnal Kedokteran Hewan","volume":"10 1","pages":"37-42"},"PeriodicalIF":0.0000,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Activities of Benzopyran (Chromones) and Benzofuranones (Coumaranones) Derivatives against Steinernema feltiae\",\"authors\":\"K. Khairan, M. Bahi, C. Jacob, R. Idroes\",\"doi\":\"10.21157/J.KED.HEWAN.V10I1.3368\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study was purposed to inquire the activities of benzopyran (chromones) and benzofuranones (coumaranones) derivatives against Steinernema feltiae (S. feltiae). The toxicity assay against S. feltiae showed that benzopyran derivatives 2, 3, 4, 6, and 9 have the highest activity on S. feltiae with viabilities percentage of <50%. The compound 9 demostrated the highest activity with LD 50 and LD values, 7.2 and 52.2 μM, respectively. The activities of compound 7 and 10 showed the lowest toxicity. Interestingly, the activity of benzofuranone derivatives showed significant activities against S. feltiae. Compare to benzopyran derivatives, the benzofuranone derivatives has the highest toxicity, in particular compound 13 with LD 5.45 μM. The nematicidal assay showed that benzofuranones (coumaranones) derivatives revealed higher activities than benzopyran (chromones) derivatives. Key words: chromones, benzopyran, coumaranones, benzofuranone, and Steinernema feltiae\",\"PeriodicalId\":30999,\"journal\":{\"name\":\"Jurnal Kedokteran Hewan\",\"volume\":\"10 1\",\"pages\":\"37-42\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jurnal Kedokteran Hewan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21157/J.KED.HEWAN.V10I1.3368\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jurnal Kedokteran Hewan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21157/J.KED.HEWAN.V10I1.3368","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本研究旨在探讨苯并吡喃(色酮)和苯并呋喃酮(香豆酮)衍生物对feltiae (S. feltiae) steinnema feltiae的活性。结果表明，苯并吡喃衍生物2、3、4、6、9对菲氏夜蛾的毒力最强，毒力<50%。其中化合物9的活性最高，LD值分别为7.2 μM和52.2 μM。化合物7和10的毒性最低。有趣的是，苯并呋喃酮衍生物的活性显示出显著的对飞蛾的活性。与苯并吡喃衍生物相比，苯并呋喃酮衍生物的毒性最高，特别是化合物13，其LD为5.45 μM。杀线虫实验表明，苯并呋喃酮(香豆酮)衍生物的杀线虫活性高于苯并吡喃(色酮)衍生物。关键词:色酮，苯并吡喃，香豆酮，苯并呋喃酮，斯坦纳菌
The Activities of Benzopyran (Chromones) and Benzofuranones (Coumaranones) Derivatives against Steinernema feltiae
This study was purposed to inquire the activities of benzopyran (chromones) and benzofuranones (coumaranones) derivatives against Steinernema feltiae (S. feltiae). The toxicity assay against S. feltiae showed that benzopyran derivatives 2, 3, 4, 6, and 9 have the highest activity on S. feltiae with viabilities percentage of <50%. The compound 9 demostrated the highest activity with LD 50 and LD values, 7.2 and 52.2 μM, respectively. The activities of compound 7 and 10 showed the lowest toxicity. Interestingly, the activity of benzofuranone derivatives showed significant activities against S. feltiae. Compare to benzopyran derivatives, the benzofuranone derivatives has the highest toxicity, in particular compound 13 with LD 5.45 μM. The nematicidal assay showed that benzofuranones (coumaranones) derivatives revealed higher activities than benzopyran (chromones) derivatives. Key words: chromones, benzopyran, coumaranones, benzofuranone, and Steinernema feltiae
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