心脏老化和年轻化的代谢靶点

The journal of cardiovascular aging Pub Date : 2022-01-01 DOI:10.20517/jca.2022.31

Chang Liu, Xiao Zhang, Meiyu Hu, Yi Lu, P. Gokulnath, Gururaja Vulugundam, Junjie Xiao

{"title":"心脏老化和年轻化的代谢靶点","authors":"Chang Liu, Xiao Zhang, Meiyu Hu, Yi Lu, P. Gokulnath, Gururaja Vulugundam, Junjie Xiao","doi":"10.20517/jca.2022.31","DOIUrl":null,"url":null,"abstract":"Cardiac aging is accompanied by progressive loss of cellular function, leading to impaired heart function and heart failure. There is an urgent need for efficient strategies to combat this age-related cardiac dysfunction. A growing number of events suggest that age-related cardiac diseases are tightly related to metabolic imbalance. This review summarizes recent findings concerning metabolic changes during cardiac aging and highlights the therapeutic approaches that target metabolic pathways in cardiac aging.","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Metabolic targets in cardiac aging and rejuvenation\",\"authors\":\"Chang Liu, Xiao Zhang, Meiyu Hu, Yi Lu, P. Gokulnath, Gururaja Vulugundam, Junjie Xiao\",\"doi\":\"10.20517/jca.2022.31\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cardiac aging is accompanied by progressive loss of cellular function, leading to impaired heart function and heart failure. There is an urgent need for efficient strategies to combat this age-related cardiac dysfunction. A growing number of events suggest that age-related cardiac diseases are tightly related to metabolic imbalance. This review summarizes recent findings concerning metabolic changes during cardiac aging and highlights the therapeutic approaches that target metabolic pathways in cardiac aging.\",\"PeriodicalId\":75051,\"journal\":{\"name\":\"The journal of cardiovascular aging\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The journal of cardiovascular aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20517/jca.2022.31\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The journal of cardiovascular aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20517/jca.2022.31","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

摘要

心脏老化伴随着细胞功能的逐渐丧失，导致心功能受损和心力衰竭。迫切需要有效的策略来对抗这种与年龄相关的心功能障碍。越来越多的事件表明，与年龄相关的心脏疾病与代谢失衡密切相关。本文综述了心脏衰老过程中代谢变化的最新发现，并重点介绍了针对心脏衰老代谢途径的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Metabolic targets in cardiac aging and rejuvenation

Cardiac aging is accompanied by progressive loss of cellular function, leading to impaired heart function and heart failure. There is an urgent need for efficient strategies to combat this age-related cardiac dysfunction. A growing number of events suggest that age-related cardiac diseases are tightly related to metabolic imbalance. This review summarizes recent findings concerning metabolic changes during cardiac aging and highlights the therapeutic approaches that target metabolic pathways in cardiac aging.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The journal of cardiovascular aging

CiteScore

2.40

自引率

0.00%

发文量