Estudo de sistemas acrílicos bioadesivos para liberação sustentada in vitro de fluoreto

The authors developed sustained fluoride release devices for intraoral application. The drug used, sodium fluoride, was associated to a mixture of polimethylmetacrilate and hydroxiethylmetacrilate, acrylic resins that formed the systems. The finished product presented an adequate behavior in terms of fluoride release and period of time in the oral cavity, as it remained in the mouth for a relatively long time (10 days), continuously liberating small quantities of the drug. These devices have several advantages concerning about drug dosage, mainly by supplying the drug to the right place (target), and maintaining it continuously in the site in an efficient and safe concentration. The development of these devices is the beginning of a field of new therapies.