{"title":"运动神经元疾病和肌萎缩侧索硬化症的研究进展","authors":"B. Kakulas","doi":"10.17756/jnen.2021-088","DOIUrl":null,"url":null,"abstract":"Several genetic makers have been identified as predisposing factors in the aetiology of motor neuron disease, MND /ALS. Chief among these are mutations in the SOD1 gene but many other aberration of the genome have been implicated mainly in the form of structural variants (SVs). Comparison is made between sporadic MND/ALS and a similar degenerative disorder endemic on the island of Guam known to be caused by Cycad toxicity. The long incubation period of both conditions points to a complex time-dependent pathogenesis.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Perspectives in Motor Neuron Disease and Amyotrophic Lateral Sclerosis\",\"authors\":\"B. Kakulas\",\"doi\":\"10.17756/jnen.2021-088\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Several genetic makers have been identified as predisposing factors in the aetiology of motor neuron disease, MND /ALS. Chief among these are mutations in the SOD1 gene but many other aberration of the genome have been implicated mainly in the form of structural variants (SVs). Comparison is made between sporadic MND/ALS and a similar degenerative disorder endemic on the island of Guam known to be caused by Cycad toxicity. The long incubation period of both conditions points to a complex time-dependent pathogenesis.\",\"PeriodicalId\":91755,\"journal\":{\"name\":\"Journal of neurology and experimental neuroscience\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of neurology and experimental neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17756/jnen.2021-088\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neurology and experimental neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17756/jnen.2021-088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Perspectives in Motor Neuron Disease and Amyotrophic Lateral Sclerosis
Several genetic makers have been identified as predisposing factors in the aetiology of motor neuron disease, MND /ALS. Chief among these are mutations in the SOD1 gene but many other aberration of the genome have been implicated mainly in the form of structural variants (SVs). Comparison is made between sporadic MND/ALS and a similar degenerative disorder endemic on the island of Guam known to be caused by Cycad toxicity. The long incubation period of both conditions points to a complex time-dependent pathogenesis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
