组蛋白表观遗传修饰及其与癌症的关系:比较医学观点

IF 0.8 4区农林科学 Q3 AGRONOMY

Ciencia Rural Pub Date : 2023-05-15 DOI:10.1590/0103-8478cr20220510

I. Senhorello, M. Tinucci-Costa

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引用次数: 0

摘要

摘要:表观遗传修饰在癌症发病机制的研究中变得非常重要，因为研究表明dna相关蛋白表达的变化可以影响基因表达，但在治疗后可能是可逆的。变化的组蛋白正在医学上进行大规模的研究，而最近的研究也显示了兽医学中的这种关系。组蛋白去乙酰化与肿瘤进展有关，组蛋白去乙酰化酶(hdac)的过度表达是导致这些变化的原因。与表观遗传变化相关的肿瘤抑制基因的沉默有利于肿瘤的进展;然而，使用HDAC抑制剂已被证明可以有效地逆转这些组蛋白变化，同时具有抗癌作用。本研究综述了人类和狗在表观遗传变化方面的比较医学研究，同时揭示了癌症与表观遗传学的生理机制和关系，特别是组蛋白乙酰化和去乙酰化。这一综述将有助于更好地理解表观遗传学和癌症，以及它们与兽医学中新的靶向分子疗法的关系，以及这些研究的重要性。

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Histone epigenetic modifications and their relationship with cancer: a comparative medicine view

ABSTRACT: Epigenetic modifications have become highly important in the study of cancer pathogenesis due to research showing that changes in the expression of DNA-associated proteins can affect gene expression but may be reversible after treatment. The changing histones are being studied on a large scale in medicine while recent studies also show this relationship in veterinary medicine. Histone deacetylation is related to tumor progression and overexpression of histone deacetylases (HDACs) is responsible for these changes. The silencing of tumor suppressor genes related to epigenetic changes favors tumor progression; however, using HDAC inhibitors has been shown to effectively reverse these histone changes while having anticancer effects. This research provided an overview of comparative medicine between humans and dogs concerning epigenetic changes while showing the physiological mechanisms and the relationship between cancer and epigenetics, specifically regarding histone acetylation and deacetylation. This overview should contribute to a better understanding of epigenetics and cancer and their relationship with new target-molecular therapies in veterinary medicine and the importance of such studies.

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来源期刊

Ciencia Rural AGRONOMY-

CiteScore

1.70

自引率

0.00%

发文量

233

审稿时长

2-4 weeks

期刊介绍： The purpose of Ciência Rural is to publish the results of original research, note and reviews which contribute significantly to knowledge in Agricultural Sciences. Preference will be given to original articles that develop news concepts or experimental approaches and are not merely repositories of scientific data. The decison of acceptance for publication lies with the Editors and is based on the recommendations of Editorial Comission, Area Committee and/ or ad hoc reviewers. The editors and reviewers are external to the institution.