南非妇女用达匹维林阴道环预防艾滋病毒

IF 4 4区 医学 Q1 INFECTIOUS DISEASES
Katherine Gill, L. Bekker
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引用次数: 0

摘要

在南非,年轻妇女仍然不成比例地受到艾滋病毒流行病的影响。临床试验表明,达匹维林阴道环(DVR)在减少女性艾滋病毒感染方面是安全有效的。2022年3月,南非保健品管理局批准在不能或不愿使用口服暴露前预防的18岁及以上妇女中使用DVR,作为预防面临重大风险妇女感染艾滋病毒的额外选择。建模研究表明,如果将DVR优先用于艾滋病毒高风险妇女或22-29岁妇女,则可能产生重大影响。DVR在南非获得许可是一个里程碑式的事件,使第一个长效和妇女控制的艾滋病毒预防方法向需要它的人又迈进了一步。在南非准备引入DVR的过程中,至关重要的是要审查未满足的艾滋病毒预防需求,并审查导致DVR获得批准的临床试验数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dapivirine Vaginal Ring for HIV Prevention in Women in South Africa
Young women remain disproportionately affected by the HIV epidemic in South Africa. Clinical trials have shown that the dapivirine vaginal ring (DVR) is safe and effective at reducing HIV infection in women. In March 2022, the South African Health Products Regulatory Authority approved the use of the DVR in women aged 18 years and older who are unable or unwilling to use oral pre-exposure prophylaxis, as an additional choice for preventing HIV in women at substantial risk. Modelling studies have suggested that the DVR could have a substantial impact if prioritized for women at substantial risk of HIV or women aged 22–29 years. The licensing of the DVR in South Africa is a milestone event that brings the first long-acting and woman-controlled HIV prevention method another step closer to reaching the people who need it. As South Africa prepares its introduction, it is critical to examine the unmet need for HIV prevention and to review the clinical trial data that led to the DVR's approval.
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来源期刊
Infectious Diseases
Infectious Diseases INFECTIOUS DISEASES-
CiteScore
8.20
自引率
1.70%
发文量
92
审稿时长
8 weeks
期刊介绍: Infectious Diseases (formerly Scandinavian Journal of Infectious Diseases) is a peer-reviewed journal publishing articles on all aspects of human infection, including pathogenesis, diagnosis, and treatment of infectious diseases, and also on medical microbiology and epidemiology
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