乳腺肿瘤母狗肾脏b超及多普勒超声辅助化疗

IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES
Lígia O. Pinto da Silva, M. C. S. Santos, Bianca F. Pina, Guilherme N. Souza, M. L. G. Ferreira
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引用次数: 0

摘要

摘要:乳腺肿瘤是母狗中最常见的肿瘤类型。虽然手术切除是治疗管理的选择,但化疗方案似乎是重要的盟友和辅助手段。尽管在癌症治疗领域取得了巨大的进步,但这些药物的全身反应仍然对其使用施加了重要的限制。从这个意义上说,越来越有针对性的治疗方案的发展和患者的预防性监测是避免可能的并发症的重要策略-其中包括急性肾损伤(AKI)。通常,超声评估用于识别腹腔器官的形态学或转移性变化。作为b型评价的补充,多普勒成像在识别血管血流动力学改变方面是有效的。因此,本研究的目的是评估b超和多普勒超声在乳腺肿瘤母狗接受吉西他滨联合卡铂辅助化疗方案时肾脏形态学和血流动力学改变的应用。包括13只母狗,不分品种,年龄在7到13岁之间。在连续三个化疗周期的两个不同时间对动物进行超声评估:每个周期前(T0)和一个半小时后(T1),持续42天。在整个化疗过程中,b模式未见形态学改变。然而,多普勒测速指标在给药前(T0)和给药后(T1)有统计学差异。结论多普勒超声可作为监测肾毒性药物暴露及可能引起肾损伤患者肾脏反应的补充方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
B-mode and Doppler ultrasound of bitches’ kidneys with mammary neoplasia submitted to adjuvant chemotherapy
ABSTRACT: Mammary neoplasia represents the most frequently diagnosed type of neoplasia in bitches. Although surgical removal is the procedure of choice for therapeutic management, chemotherapy protocols appear as important allies and adjuvants. Despite the great advances that have occurred in the field of cancer therapy, the systemic repercussions of these drugs still impose important limitations on their use. In this sense, the development of increasingly targeted therapeutic protocols and preventive monitoring of patients represent important strategies to avoid possible complications - among them, Acute Kidney Injury (AKI). Routinely, ultrasound evaluation is used to identify morphological or metastatic variations in abdominal cavity organs. Acting complementary to the B-mode evaluation, Doppler mapping proves to be efficient in recognizing alterations in vascular hemodynamics. Therefore, the objective of the present study was to evaluate the use of B-mode and Doppler ultrasound to identify renal morphological and hemodynamic alterations in bitches with mammary neoplasia submitted to adjuvant chemotherapy protocols that associate gemcitabine with carboplatin. Thirteen bitches were included, without distinction of breed and between seven and 13 years of age. The animals were evaluated ultrasonographically at two different times during three consecutive chemotherapy cycles: before (T0) and one and a half hours after each cycle (T1), for 42 days. No morphological changes were observed in B-mode throughout the chemotherapy protocol. However, the Doppler velocimetry indices demonstrated statistical differences before (T0) and after (T1) the administration of the drugs. It was concluded that Doppler ultrasound could be used as a complementary method for monitoring the renal response of patients exposed to nephrotoxic drugs and potentially causing renal injury.
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来源期刊
Pesquisa Veterinaria Brasileira
Pesquisa Veterinaria Brasileira 农林科学-兽医学
CiteScore
1.30
自引率
16.70%
发文量
41
审稿时长
9-18 weeks
期刊介绍: Pesquisa Veterinária Brasileira - Brazilian Journal of Veterinary Research (http://www.pvb.com.br), edited by the Brazilian College of Animal Pathology in partnership with the Brazilian Agricultural Research Organization (Embrapa) and in collaboration with other veterinary scientific associations, publishes original papers on animal diseases and related subjects. Critical review articles should be written in support of original investigation. The editors assume that papers submitted are not being considered for publication in other journals and do not contain material which has already been published. Submitted papers are peer reviewed. The abbreviated title of Pesquisa Veterinária Brasileira is Pesqui. Vet. Bras.
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