{"title":"网膜内ATP嗜水功能在白内障发生和老年性阿片发生中的意义","authors":"J. Greiner, T. Glonek","doi":"10.15761/NFO.1000247","DOIUrl":null,"url":null,"abstract":"Adenosine triphosphate (ATP) prevents protein aggregation. The crystalline lens, although a metabolically quiescent organ, synthesizes a large amount of ATP, ca. 3 mM [1], that exceeds by an order-of-magnitude the concentration required for all the known intracellular functions of ATP, combined. This high intralenticular ATP concentration is shared by many species including humans [2,3]. The production of such an excessive amount of ATP is inconsistent with the usual conservative production of ATP assumed to be operant in nature, which brings into question why such a high concentration of ATP exists in the lens.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Implications of the hydrotropic function of intralenticular ATP in cataractogenesis and presbyopiogenesis\",\"authors\":\"J. Greiner, T. Glonek\",\"doi\":\"10.15761/NFO.1000247\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Adenosine triphosphate (ATP) prevents protein aggregation. The crystalline lens, although a metabolically quiescent organ, synthesizes a large amount of ATP, ca. 3 mM [1], that exceeds by an order-of-magnitude the concentration required for all the known intracellular functions of ATP, combined. This high intralenticular ATP concentration is shared by many species including humans [2,3]. The production of such an excessive amount of ATP is inconsistent with the usual conservative production of ATP assumed to be operant in nature, which brings into question why such a high concentration of ATP exists in the lens.\",\"PeriodicalId\":91933,\"journal\":{\"name\":\"New frontiers in ophthalmology (London)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New frontiers in ophthalmology (London)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15761/NFO.1000247\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New frontiers in ophthalmology (London)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/NFO.1000247","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Implications of the hydrotropic function of intralenticular ATP in cataractogenesis and presbyopiogenesis
Adenosine triphosphate (ATP) prevents protein aggregation. The crystalline lens, although a metabolically quiescent organ, synthesizes a large amount of ATP, ca. 3 mM [1], that exceeds by an order-of-magnitude the concentration required for all the known intracellular functions of ATP, combined. This high intralenticular ATP concentration is shared by many species including humans [2,3]. The production of such an excessive amount of ATP is inconsistent with the usual conservative production of ATP assumed to be operant in nature, which brings into question why such a high concentration of ATP exists in the lens.