危重病人的糖皮质激素受体

A. Vassiliou, G. Stamogiannos, G. Floros, A. Kotanidou, I. Dimopoulou
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引用次数: 0

摘要

在危重患者中,下丘脑-垂体-肾上腺轴被激活,因此这些患者表现出血清皮质醇浓度升高。然而,许多患者的皮质醇水平相对较低,与疾病严重程度相关。糖皮质激素的作用由糖皮质激素受体促进,其功能障碍导致糖皮质激素组织抵抗。大多数危重成人患者的临床研究都研究了皮质醇的可用性,只有少数研究了糖皮质激素受体的水平和功能。在这篇综述中,我们将探讨从临床研究中产生的相互矛盾的结果,旨在阐明糖皮质激素受体在糖皮质激素耐药中的作用。受体功能和表达的研究可能有助于确定将受益于皮质类固醇治疗的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glucocorticoid receptors in critically ill patients
In critically ill patients, the hypothalamic-pituitary-adrenal axis is activated and as a consequence these patients exhibit increased serum cortisol concentrations. However, a number of patients have relatively low cortisol levels for the degree of illness severity. Glucocorticoid actions are facilitated by the glucocorticoid receptor whose dysfunction leads to glucocorticoid tissue resistance. Most clinical studies in critically ill adult patients have studied cortisol availability, and only a few have investigated glucocorticoid receptor levels and function. In this review we will explore the conflicting results that have arisen from the clinical studies that aimed to elucidate the role of glucocorticoid receptor in glucocorticoid resistance. The study of receptor function and expression might aid in identifying the patients who will benefit from corticosteroid administration.
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