S. Cacciapuoti, C. Marasca, M. Luciano, A. Masarà, M. Donnarumma, A. Balato, G. Fabbrocini
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mTOR in inflammatory skin diseases: Review of the literature and our experience
The mTORC1 protein complex consists of multiple components such as the serine/threonine kinase mTOR and the regulatoryassociated protein of mTOR (Raptor). Three highly researched upstream modulators of mTOR are the phosphatidylinositol 3-kinases (PI3Ks), protein kinase B (Akt). PI3K, and tumor necrosis factor alpha (TNFa) regulates Akt. Increased expression of PI3K, Akt, and TNFa amplifies mTORC1 activity as well (Figure 1) [3,4].
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