实时激光扫描共聚焦显微镜观察螺内酯诱导大鼠睾丸小动脉平滑肌细胞Ca2+升高的机制

Q4 Medicine

Archives of histology and cytology Pub Date : 2013-01-01 DOI:10.1679/AOHC.74.19

Yasunori Tamagawa, T. Saino, M. Matsuura, M. Oikawa, Y. Satoh

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引用次数: 1

摘要

总结。我们以前报道过螺内酯(SPL)诱导大鼠睾丸小动脉平滑肌细胞内ca2 +浓度([ca2 +]i)的增加。在本研究中，我们进一步研究了spll诱导大鼠小动脉平滑肌[ca2 +]i动力学的机制。SPL (300 μM)诱导的[ca2 +]i的增加在细胞外无ca2 +条件下明显被抑制

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Mechanism of spironolactone-induced Ca2+ increase in rat testicular arteriole smooth muscle cells revealed by real-time laser scanning confocal microscopy

Summary. We reported previously that spironolactone (SPL) induced an increase in intracellular Ca 2+ concentration ([Ca 2+ ]i) in rat testicular arteriole smooth muscle cells. In the present study, we further investigated the mechanism of SPL-induced [Ca 2+ ]i dynamics in rat arteriole smooth muscles. The increase in [Ca 2+ ]i induced by SPL (300 μM) was markedly inhibited in extracellular Ca 2+ -free conditions and in

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来源期刊

Archives of histology and cytology 生物-细胞生物学

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期刊介绍： The Archives of Histology and Cytology provides prompt publication in English of original works on the histology and histochemistry of man and animals. The articles published are in principle restricted to studies on vertebrates, but investigations using invertebrates may be accepted when the intention and results present issues of common interest to vertebrate researchers. Pathological studies may also be accepted, if the observations and interpretations are deemed to contribute toward increasing knowledge of the normal features of the cells or tissues concerned. This journal will also publish reviews offering evaluations and critical interpretations of recent studies and theories.