西叶提取物对疟疾性贫血大鼠堆积细胞体积的影响

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie Pub Date : 2020-01-01 DOI:10.17159/0379-4350/2020/v73a8

C. Ikese, S. T. Ubwa, S. Adoga, S. Audu, M. I. Kuleve, F. O. Okita, A. Okoh

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引用次数: 0

摘要

大多数疟疾药物中的生物活性成分仅能减少化疗期间的疟原虫负荷。没有抗疟疾药物可以补充被疟原虫破坏的红细胞。这就需要在疟疾治疗中加入具有血液特性的生物活性成分。本研究旨在探讨西叶提取物对疟疾性贫血大鼠堆积细胞体积(PCV)的影响。给大鼠接种伯氏疟原虫诱导其贫血。在阴性对照和阳性对照的同时，测定了植物提取物对大鼠PCV的影响。测定了不同剂量提取物对大鼠PCV的影响。西叶提取物可使接种后大鼠PCV增加22%。阴性对照组和阳性对照组PCV分别下降37%和25%。此外，PCV随提取物剂量的增加而增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of Telfaira occidentalis Leaf Extract on Packed Cell Volume in Rats with Malaria-induced Anaemia

The bioactive ingredients in most malarial drugs only reduce plasmodium load during chemotherapy. No anti-malarial drug replenishes the red blood cells destroyed by Plasmodium. This creates a need to incorporate bioactive components with haematinic property in malaria therapy. This study aimed to assess the effect of T. occidentalis leaf extract on packed cell volume (PCV) of rats with malaria-induced anaemia. Anaemia was induced in the rats by inoculating them with Plasmodium berghei. The effect of the plant extract on the PCV of the rats was determined alongside a negative and a positive control. Also, the effect of varying doses of the extract on PCV of the rats was determined. T. occidentalis leaf extract produced a 22 % increase in the post-inoculation PCV of rats. The negative and positive control groups showed a 37 % and 25 % decrease, respectively, in PCV. Also, PCV increased with increase in extract dose administered.

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来源期刊

South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie 化学-化学综合

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Original work in all branches of chemistry is published in the South African Journal of Chemistry. Contributions in English may take the form of papers, short communications, or critical reviews.