新型铬烯和[2,3-d]嘧啶的合成及生物学评价

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie Pub Date : 2021-01-01 DOI:10.17159/0379-4350/2021/v75a18

F. Belhadj, Z. Kibou, M. Benabdallah, M. Aissaoui, M. Rahmoun, D. Villemin, N. Choukchou-Braham

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引用次数: 2

摘要

开发了一种简单有效的方法来合成新的功能化5H-chromeno[2,3-d]嘧啶衍生物(4a-h)。这种方法需要在微波照射和无溶剂条件下用醋酸甲脒处理2-氨基-3-氰基- 4h -铬(3a-h)。通过IR、MS、1H和13C NMR对新化合物的结构进行了表征。此外，还研究了合成的化合物的抗菌和抗氧化能力。化合物3b、3c、3e、4c和4e具有显著活性。关键词:5h -色[2,3-d]嘧啶;4 h-chromene;无溶剂条件;抗氧化活性;抗菌活性

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Synthesis and Biological Evaluation of New Chromenes and Chromeno[2,3-d] pyrimidines

ABSTRACT A simple and efficient approach has been developed to synthesise novel and functionalised 5H-chromeno[2,3-d] pyrimidines derivatives (4a-h). This approach entails treating 2-amino-3-cyano-4H-chromenes (3a-h) with formamidine acetate under microwave irradiations and solvent-free conditions. All structures of new compounds obtained in this study were characterised by IR, MS, 1H and 13C NMR analysis. Additionally, the synthesised compounds were investigated for their antibacterial and antioxidant potential. Compounds 3b, 3c, 3e, 4c and 4e showed significant activities. Keywords: 5H-chromeno[2,3-d] pyrimidine; 4H-chromene; solvent-free conditions; antioxidant activity; antibacterial activity

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来源期刊

South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie 化学-化学综合

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Original work in all branches of chemistry is published in the South African Journal of Chemistry. Contributions in English may take the form of papers, short communications, or critical reviews.