新型香豆素衍生物:合成、表征及抗菌活性

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie Pub Date : 2019-01-01 DOI:10.17159/0379-4350/2019/v72a32

C. G. Naik, G. Malik, H. Parekh

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引用次数: 9

摘要

以邻乙酰氧基苯甲酸和亚硫酰氯为原料，得到2-乙酰氧基苯甲酰氯，再与乙酰乙酸乙酯反应得到4-羟基香豆素，合成了新的香豆素衍生物2,3,4,5,6,7。取代吡唑酮和噻唑与4-羟基香豆素反应得到吡唑酮和甲基噻唑类香豆素衍生物。用红外、氢、碳核磁共振、质谱技术和元素分析对合成产物进行了表征。对合成的化合物进行了抗菌和抗真菌活性的筛选。所有化合物均对所测微生物具有显著活性。

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Novel Coumarin Derivatives: Synthesis, Characterization and Antimicrobial Activity

The novel coumarin derivatives (2, 3, 4, 5, 6, 7) have been synthesized from the reaction of o-acetyloxy benzoic acid with thionyl chloride yielding 2-acetoxy benzoyl chloride, which on further treatment with ethylacetoacetate gave 4-hydroxycoumarin. Substituted pyrazolones and thiazoles reacted with 4-hydroxy coumarin to give pyrazolones and methyl thiazoles related coumarin derivatives. The newly synthesized products were characterized with IR, H and C NMR, mass spectroscopic techniques and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activity. All the compounds were found to have significant activity against the tested microorganisms.

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来源期刊

South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie 化学-化学综合

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Original work in all branches of chemistry is published in the South African Journal of Chemistry. Contributions in English may take the form of papers, short communications, or critical reviews.