铝催化氧化人体血液中扑热息痛作用的电化学评价

IF 0.7 Q4 CHEMISTRY, ANALYTICAL

Methods and Objects of Chemical Analysis Pub Date : 2021-01-01 DOI:10.17721/moca.2021.162-168

Hayat El ouafy, T. EL Ouafy, M. Oubenali, Aziz El Haimouti, A. Gamouh, M. Mbarki

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引用次数: 1

摘要

报道了铝改性碳糊电极(CPE)对扑热息痛(Pa)的反应性。将铝与碳粉混合制成工作电极。在-1.7 V ~ 1.7 V范围内选择最佳电位窗。循环伏安法(CV)和方波伏安法(SWV)对pH、扫描速率、积累时间和浓度等参数的影响进行了研究。最佳预浓缩时间为8分钟。在硫酸钠溶液(0.1 M, pH 7)中，在0.25 V时出现阳极峰表征了Pa在电分析检测器上的反应性，计算出的检测限和定量限分别为8.28·10-9和2.74·10-8 mol L-1。在2.0·10-5 mol L-1 Pa浓度下，9次重复的相对标准偏差(RSD)为4.08%。将该方法应用于人体血液中Pa的检测，结果令人满意。

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Electrochemical Evaluation of Catalytic Effect of Aluminum in Oxidation the Paracetamol in Human Blood

The reactivity of paracetamol (Pa) using the carbon paste electrode (CPE) modified by the aluminum (CPE-Al) was reported. The working electrode was prepared by mixing the aluminum with the carbon powder. The optimal potential window was selected from -1.7 V to 1.7 V. The effect of parameters such as pH, scan rate, accumulation time and concentration were affected by cyclic voltammetry (CV) and square wave voltammetry (SWV). The optimal preconcentration time is 8 minutes. The reactivity of Pa on the electroanalysis detector was characterized by the appearance of the anodic peak at 0.25 V in a solution of sodium sulfate (0.1 M, pH 7). The calculated limits of detection and quantification have been 8.28·10-9 and 2.74·10-8 mol L-1, respectively. Then relative standard deviation (RSD) at 2.0·10-5 mol L-1 Pa concentration was 4.08 % for nine repetitions. The analytical application was carried out in the detection of Pa in human blood with satisfying results.

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来源期刊

Methods and Objects of Chemical Analysis CHEMISTRY, ANALYTICAL-

CiteScore

1.00

自引率

14.30%

发文量

期刊介绍： The journal "Methods and objects of chemical analysis" is peer-review journal and publishes original articles of theoretical and experimental analysis on topical issues and bio-analytical chemistry, chemical and pharmaceutical analysis, as well as chemical metrology. Submitted works shall cover the results of completed studies and shall make scientific contributions to the relevant area of expertise. The journal publishes review articles, research articles and articles related to latest developments of analytical instrumentations.