氧化衍生法测定药物制剂中哌嗪的含量

IF 0.7 Q4 CHEMISTRY, ANALYTICAL

Methods and Objects of Chemical Analysis Pub Date : 2020-01-01 DOI:10.17721/moca.2020.21-26

M. Blazheyevskiy, Y. Scrypynets, A. Yegorova, V. Antonovich

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引用次数: 0

摘要

建立了氧化衍生化间接荧光光谱法测定哌嗪的方法。氢过氧单硫酸氢钾(Oxone®)被提出作为Periciazine的衍生化剂，生成强荧光Periciazine亚砜。用Oxone®溶液在0.02 M盐酸溶液中(λex = 364 nm;λem = 444 nm)。校正图在0.05 ~ 4.00µg mL -1浓度范围内呈线性关系。定量限(10S)为0.05µg mL -1。定量测定药物制剂(Neuleptil®，10 mg胶囊和Neuleptil®，30 mL 4%口服(溶液)滴剂)中哌嗪的可能性显示RSD < 2.2% (δ < RSD)。

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The Oxidative Derivatization Method For The Spectrofluorimetric Determination Of Periciazine In Pharmaceutical Preparations

The oxidative derivatization method for the indirect spectrofluorimetric determination of Periciazine has been presented. Potassium hydrogenperoxymonosulfate (Oxone ®) is proposed as a derivatizing agent for Periciazine, yielding the strongly fluorescent Periciazine sulfoxide. A highly sensitive, simple and rapid method for determination of the Periciazine by fluorescence of its oxidation product with Oxone ® solution in 0.02 M hydrochloric acid solution (λex = 364 nm; λem = 444 nm) has been developed. The calibration plot is linear in concentration range of 0.05 – 4.00 µg mL -1 . LOQ (10S) is 0.05 µg mL -1 . The possibility of quantitative determination of Periciazine in pharmaceutical preparations (Neuleptil ®, 10 mg capsules and Neuleptil ®, a 30 mL 4 % oral (solution) drops) has been shown RSD < 2.2 % (δ < RSD).

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来源期刊

Methods and Objects of Chemical Analysis CHEMISTRY, ANALYTICAL-

CiteScore

1.00

自引率

14.30%

发文量

期刊介绍： The journal "Methods and objects of chemical analysis" is peer-review journal and publishes original articles of theoretical and experimental analysis on topical issues and bio-analytical chemistry, chemical and pharmaceutical analysis, as well as chemical metrology. Submitted works shall cover the results of completed studies and shall make scientific contributions to the relevant area of expertise. The journal publishes review articles, research articles and articles related to latest developments of analytical instrumentations.