氧化衍生间接荧光光谱法测定药物制剂中马来酸丙氯哌嗪含量的新方法

IF 0.7 Q4 CHEMISTRY, ANALYTICAL

Methods and Objects of Chemical Analysis Pub Date : 2019-01-01 DOI:10.17721/moca.2019.140-145

M. Blazheyevskiy, Yu. V. Skrypynets, A. Yegorova, V. Antonovich

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引用次数: 0

摘要

提出了一种新的氧化衍生化间接荧光光谱法测定马来酸丙氯哌嗪的方法。提出了氢过氧一硫酸钾作为丙氯哌嗪的衍生剂，生成强荧光亚砜。该反应产物成功地用于马来酸丙氯哌嗪的荧光光度测定。建立了马来酸丙氯哌嗪片中马来酸丙氯哌嗪片在0.01 M硫酸溶液(λex = 340 nm;λem = 380 nm)。在0.8 ~ 10.0µg/ml的浓度范围内，校准曲线呈线性关系。定量限(LOQ = 10S)为0.8µg/ml。本方法可用于Vertinex®片剂中马来酸丙氯哌嗪的定量测定，RSD <2.3% (δ

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A New Oxidative Derivatization Method For The Indirect Spectrofluorimetric Determination Of Prochlorperazine Maleate In Pharmaceutical Preparations

A new oxidative derivatization method for the indirect spectrofluorimetric determination of Prochlorperazine maleate has been presented. Potassium hydrogenperoxomonosulphate is proposed as a derivatizing agent for Prochlorperazine, yielding the strongly fluorescent sulfoxide. This reaction product was successfully employed for the spectrofluorimetric determination of the Prochlorperazine maleate. A highly sensitive, simple and rapid method has been developed for determining prochlorperazine maleate in tablets by fluorescence of its oxidation product with Oxone solution in 0.01 M sulfuric acid solution (λex = 340 nm; λem = 380 nm). The calibration curve is linear in its concentration range of 0.8–10.0 µg/ml. Limit of quantification (LOQ = 10S) is 0.8 µg/ml. The possibility of quantitative determination of Prochlorperazine maleate in Vertinex® tablets 5 mg has been shown, RSD <2.3% (δ

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来源期刊

Methods and Objects of Chemical Analysis CHEMISTRY, ANALYTICAL-

CiteScore

1.00

自引率

14.30%

发文量

期刊介绍： The journal "Methods and objects of chemical analysis" is peer-review journal and publishes original articles of theoretical and experimental analysis on topical issues and bio-analytical chemistry, chemical and pharmaceutical analysis, as well as chemical metrology. Submitted works shall cover the results of completed studies and shall make scientific contributions to the relevant area of expertise. The journal publishes review articles, research articles and articles related to latest developments of analytical instrumentations.