K. Kasem, D. Ager, F. Nerozzi, Weiping Liu, Xi-zhu Chen, Qingsong Ye, Shuqian Hou, L. Lou, Xie Chengying
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3-Hydroxycarboplatin, a Simple Carboplatin Derivative Endowed with an Improved Toxicological Profile
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China *Email: liguanglou1@126.com 3-Hydroxycarboplatin, a simple carboplatin derivative, was synthesised using a novel method, characterised and evaluated for its anticancer activity in vitro and in vivo. It shows comparable antitumour activity to that of carboplatin but has much lower toxicity particularly with respect to myelosuppression, revealing great potential for development as a new antitumour platinum drug to replace carboplatin.
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