{"title":"乌拉地尔对肾缺血再灌注相关肾损伤的有益作用","authors":"A. Tanyeli̇","doi":"10.14744/scie.2022.89421","DOIUrl":null,"url":null,"abstract":"Objective: The potential protective effects of urapidil (Ura) against renal injury composed by ischemia reperfusion (I/R) were examined. Methods: The experimental animals were assigned to sham, I/R, I/R + Ura 0.5 mg/kg, and I/R + Ura 5 mg/kg groups. Total antioxidant status (TAS), superoxide dismutase (SOD), total oxidant status (TOS), myeloperoxidase (MPO), oxidative stress index (OSI), and malondialdehyde (MDA) parameters were determined. Results: MDA, TOS, MPO, and OSI values elevated, but TAS and SOD levels declined in the I/R group. Ura treatment reversed these parameters. In addition, immunopositivity of interleukin-1 beta and tumor necrosis factor-alpha were severe in the I/R group but declined due to Ura administration. Conclusion: The results of the study showed that Ura is highly effective against renal damage induced by I/R. ABSTRACT","PeriodicalId":33982,"journal":{"name":"Southern Clinics of Istanbul Eurasia","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Beneficial Effects of Urapidil Against Renal Ischemia Reperfusion-Related Renal Injury\",\"authors\":\"A. Tanyeli̇\",\"doi\":\"10.14744/scie.2022.89421\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: The potential protective effects of urapidil (Ura) against renal injury composed by ischemia reperfusion (I/R) were examined. Methods: The experimental animals were assigned to sham, I/R, I/R + Ura 0.5 mg/kg, and I/R + Ura 5 mg/kg groups. Total antioxidant status (TAS), superoxide dismutase (SOD), total oxidant status (TOS), myeloperoxidase (MPO), oxidative stress index (OSI), and malondialdehyde (MDA) parameters were determined. Results: MDA, TOS, MPO, and OSI values elevated, but TAS and SOD levels declined in the I/R group. Ura treatment reversed these parameters. In addition, immunopositivity of interleukin-1 beta and tumor necrosis factor-alpha were severe in the I/R group but declined due to Ura administration. Conclusion: The results of the study showed that Ura is highly effective against renal damage induced by I/R. ABSTRACT\",\"PeriodicalId\":33982,\"journal\":{\"name\":\"Southern Clinics of Istanbul Eurasia\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Southern Clinics of Istanbul Eurasia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14744/scie.2022.89421\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Southern Clinics of Istanbul Eurasia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14744/scie.2022.89421","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:探讨乌拉地尔(Ura)对肾缺血再灌注(I/R)损伤的保护作用。方法:将实验动物分为假手术组、I/R组、I/R + Ura 0.5 mg/kg组和I/R + Ura 5 mg/kg组。测定总抗氧化状态(TAS)、超氧化物歧化酶(SOD)、总氧化状态(TOS)、髓过氧化物酶(MPO)、氧化应激指数(OSI)和丙二醛(MDA)参数。结果:I/R组MDA、TOS、MPO、OSI值升高，TAS、SOD水平下降。Ura治疗逆转了这些参数。此外，I/R组白细胞介素-1 β和肿瘤坏死因子- α的免疫阳性严重，但由于Ura给药而下降。结论:乌拉对I/R所致的肾损害有较强的抑制作用。摘要
Beneficial Effects of Urapidil Against Renal Ischemia Reperfusion-Related Renal Injury
Objective: The potential protective effects of urapidil (Ura) against renal injury composed by ischemia reperfusion (I/R) were examined. Methods: The experimental animals were assigned to sham, I/R, I/R + Ura 0.5 mg/kg, and I/R + Ura 5 mg/kg groups. Total antioxidant status (TAS), superoxide dismutase (SOD), total oxidant status (TOS), myeloperoxidase (MPO), oxidative stress index (OSI), and malondialdehyde (MDA) parameters were determined. Results: MDA, TOS, MPO, and OSI values elevated, but TAS and SOD levels declined in the I/R group. Ura treatment reversed these parameters. In addition, immunopositivity of interleukin-1 beta and tumor necrosis factor-alpha were severe in the I/R group but declined due to Ura administration. Conclusion: The results of the study showed that Ura is highly effective against renal damage induced by I/R. ABSTRACT
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