生物医学用无碱MgO-CaO-SrO-TiO2-P2O5玻璃的溶解行为和细胞相容性

Q1 Materials Science

Biomedical Glasses Pub Date : 2015-12-18 DOI:10.1515/bglass-2015-0015

Sungho Lee, A. Obata, D. Brauer, T. Kasuga

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引用次数: 9

摘要

由于其可控制的溶解度，磷酸盐倒置玻璃被用作控制离子释放的临时植入材料或组织工程支架。制备了MgO-CaO-SrO-TiO2-P2O5倒置玻璃，并对其溶解行为和细胞反应进行了研究。由于Mg2+离子相对较大的场强，在磷酸盐转化玻璃体系中加入MgO可以改善玻璃的形成。在MC3T3-E1类成骨细胞培养试验中，倒置玻璃上的细胞数量明显大于对照，这可能是由于Mg2+离子的释放促进了细胞的粘附和增殖。碱性磷酸酶(ALP)活性随玻璃成分的不同而变化，高钙取代锶(33 ~ 100%)显示出最高的ALP活性。这种效应可能是由锶离子从玻璃中释放出来引起的。

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Dissolution behavior and cell compatibility of alkali-free MgO-CaO-SrO-TiO2-P2O5 glasses for biomedical applications

Abstract Owing to their controlled solubility, phosphate invert glasses are of interest for use as temporary implant materials or tissue engineering scaffolds for controlled ion release.MgO-CaO-SrO-TiO2-P2O5 invert glasses were prepared and their dissolution behavior and cell response were examined.MgO addition to the phosphate invert glass system improved glass formation, owing to the relatively large field strength of Mg2+ ions. In osteoblastlike MC3T3-E1 cell culture tests, cell numbers on the invert glasses were significantly larger compared with the control, possibly caused by the release of Mg2+ ions promoting enhanced cell adhesion and proliferation. Alkaline phosphatase (ALP) activity varied with glass composition, with higher strontium for calcium substitution (33 to 100%) showing highest ALP activity. This effect may be caused by the release of strontium ions from the glasses.

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.