男性和女性自闭症谱系障碍儿童唾液流量和唾液蛋白:初步研究

Matheus Morcela de Souza, J. V. S. Rodrigues, Maria Eduarda Cabrerizo Gonçalves, L. Theodoro, A. C. Nakamune
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引用次数: 1

摘要

自闭症谱系障碍是一种影响联系和沟通建立的神经发育障碍。对于患有这种疾病的人来说,牙齿护理更加困难,因为除了沟通困难之外,口腔卫生方面的不合作和持续使用药物是常见的。据报道,这些人更容易患龋齿,唾液蛋白的流动和浓度也发生了变化。目的考虑到性别对自闭症儿童唾液流量和蛋白质浓度的影响,我们的目的是分析这些参数。材料和方法:在禁食和口腔卫生2小时后,在导管的帮助下,从5 - 15岁的12名男孩和12名女孩中获得总未刺激唾液。唾液流量是通过估计唾液的质量来确定的。以牛白蛋白为标准,在10,000 x g离心10分钟后,用Lowry法测定上清中的总蛋白。结果用均值和标准差表示。数据提交Shapiro-Wilk和Mann Whitney检验,显著性水平为5%。结果男孩(0.3555±0.24 ml/min)和女孩(0.2522±0.1727 ml/min)的唾液流量值,男孩(1.430±0.7480 mg/ ml)和女孩(1.075±0.3702 mg/ ml)的蛋白质值在性别间无显著差异。结论自闭症谱系障碍儿童的性别对非刺激流和唾液蛋白值无影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Salivary flow and salivary proteins in male and female children with autism spectrum disorder: pilot study
Abstract Introduction autism spectrum disorder is a neurodevelopmental condition that affects the establishment of bonds and communication. Dental care is more difficult for people with this disorder, because in addition to communication difficulties, non-cooperation with respect to oral hygiene and continuous use of medication are common. Greater predisposition to caries, as well as alterations in the flow and concentration of salivary proteins were reported in these individuals. Objective considering that sex can affect salivary flow and protein concentration, our objective was to analyze these parameters in the saliva of children with autism. Material and method total unstimulated saliva was obtained from 12 boys and 12 girls aged between 5 and 15 years, with the aid of a catheter, after 2 hours of fasting and oral hygiene. Salivary flow was determined by estimating the mass of saliva. Total protein was determined in the supernatant obtained after centrifugation at 10,000 x g, for 10 minutes, by the Lowry method, with bovine albumin as standard. The results are expressed as mean and standard deviation. The data were submitted to the Shapiro-Wilk and Mann Whitney tests, with a significance level of 5%. Result salivary flow values for boys (0.3555 ± 0.24 ml/min) and girls (0.2522 ± 0.1727 ml/min), and protein values for boys (1.430 ± 0.7480 mg/mL) and girls (1.075 ± 0.3702 mg/mL) were not significantly different between sexes. Conclusion in children with autism spectrum disorder, sex does not influence unstimulated flow and salivary protein values.
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