Can Oral hypoglycemic drugs replace Insulin for management of patients with gestational diabetes mellitus in pregnant Egyptian women’s: Observational study?

Gestational diabetes mellitus [GDM] is diagnosed when glucose intolerance starts during pregnancy.1 It occurs in 6–7% of pregnancies. These patients have more chance of maternal complications and developing diabetes in older age with many neonatal complications up to stillbirth and neonatal death.2,3 Use of insulin has been the only pharmacological line for women with GDM, but it is high cost and inconvenient.1 Many studies show that Glibenclamide and metformin can be used as insulin in controlling hyperglycemia in GDM, with no change in maternal and neonatal complications.4 The target of our study is to evaluate use of metformin or glibenclamide in glycemic control and reducing maternal and neonatal complications in GDM to assess if it is possible to replace metformin or glibenclamide instead of insulin in GDM.