基于酰基腙的动态组合文库:热力学/动力学演化、构型和配位动力学研究

IF 0.2 Q4 CHEMISTRY, MULTIDISCIPLINARY

Revista Colombiana de Quimica Pub Date : 2016-09-01 DOI:10.15446/REV.COLOMB.QUIM.V45N3.61408

M. A. Gordillo, F. Zuluaga, M. Chaur

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引用次数: 3

摘要

描述了动态组合文库(DCL)中酰基腙生成的动力学和热力学选择性。肼类化合物产生竞争反应:异烟肼、4-硝基苯并肼、4-二甲氨基苯并肼和烟碱肼;以及醛衍生物:苯甲醛和2-吡啶-甲醛。通过1h - nmr对得到的dcl的种类和分布进行了监测，发现含有4-二甲氨基-苯并酰肼的酰基腙都是它们各自文库的动力学和热力学产物。对其中一些库的构型动力学和配位动力学进行了研究。所获得的结果允许研究组分的再分配和一个或多个产品的扩增，分别使用光离子和金属离子作为物理和化学模板。

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Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics

The kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described. Competition reactions were generated from hydrazides: isoniazid, 4-nitro-benzohydrazide, 4-dimethylamino-benzohydrazide, and nicotinic hydrazide; as well as the aldehyde derivatives: benzaldehyde and 2-pyridine-carboxaldehyde. The obtained species and the distribution of the DCLs were monitored by 1 H-NMR spectroscopy finding that those acylhydrazones containing the 4-dimethylamino-benzohydrazide are both the kinetic and thermodynamic product of their respective libraries. Configurational and coordination dynamics for some of these libraries were also investigated. The obtained results allowed the study of the redistribution of components and the amplification of one or more products using light and metal ions as physical and chemical templates, respectively.

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来源期刊

Revista Colombiana de Quimica CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.50

自引率

0.00%

发文量

期刊介绍： The Revista Colombiana de Química - Colombian Journal of Chemistry (Rev. Colomb. Quim.) Is a peer-reviewed scientific journal of the Department of Chemistry, Faculty of Sciences of the Universidad Nacional de Colombia, Bogotá. It currently publishes three volumes per year: January-April, May-August and September-December. All the content published by the Journal (available online) is under a Creative Commons attribution license type BY 4.0, that allows any person or entity in the world to freely access the content, share it, download it, adapt it or make derivative works without any restriction, provided that it adequately indicates the credit to the authors and to the Colombian Journal of Chemistry.