二甲双胍对2型糖尿病患者一氧化氮生物利用度的影响

Q3 Medicine

Obesity and Metabolism Pub Date : 2012-03-15 DOI:10.14341/2071-8713-5053

I. S. Kuznetsov, Serezhenkov Va, A. Vanin, T. Romantsova

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引用次数: 0

摘要

本研究的目的是利用电子顺磁共振(EPR)技术评价接受二甲双胍治疗的2型糖尿病患者血浆亚硝酸盐和全血高铁血红蛋白水平。连续用药3个月后，剂量为1700 mg，在糖脂代谢改善、腰围缩小的同时，血浆亚硝酸盐浓度升高，全血高铁血红蛋白升高，具有统计学意义。二甲双胍治疗期间一氧化氮的生物利用度增加可能是药物作用机制的另一个解释。

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Effect of metformin on the bioavailability of nitric oxide in patients with type 2 diabetes

The aim of our study was to evaluate the levels of nitrite in plasma and methemoglobin in whole blood using electron paramagnetic resonance (EPR) in patients with type 2 diabetes mellitus receiving metformin. After 3 months of continuous use of the drug at a dose of 1700 mg in parallel with the improvement of carbohydrate and lipid metabolism, reduction in waist circumference there was a statistically significant increase in nitrite concentration in plasma and increased methemoglobin in whole blood. Increased bioavailability of nitric oxide during treatment with metformin may be an additional explanation for the mechanism of drug action.

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来源期刊

Obesity and Metabolism Medicine-Internal Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Journal "Obesity and Metabolism" is a multidisciplinary forum for clinical and applied research in the field of biochemistry, physiology, pathophysiology, genetics, nutrition, as well as molecular, metabolic, psychological and epidemiological aspects of obesity and metabolism. The main subject "Metabolism" reviewed in the journal, includes fat, carbohydrate, protein, bone, fluid and electrolyte and other types of metabolism in the spectrum of pathology of the endocrine system. The priority direction of Journal "Obesity and Metabolism" is publishing modern high-quality original research on the effectiveness of new and existing treatments in any aspect of metabolic and endocrine diseases. Pre-clinical pharmacology, pharmacokinetics studies, meta-analyzes, addressed to drug safety and tolerance are also welcome for publication in the journal "Obesity and metabolism." Journal "Obesity and Metabolism" announces review articles that are balanced, clear and offer the reader a modern and critical analysis of the literature on the subject of the magazine. Case reports, and lecture materials are also published for highlighting for practitioners new approaches to diagnosis and treatment of patients with metabolic disorders and obesity.