合成幼体激素类似物(JHA)对克氏锥虫的生物活性研究

IF 0.8 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences Pub Date : 1990-01-01 DOI:10.1515/znb-1990-0119

A. Stoka, C. Rivas, E. Segura, Juan B Rodriguez, E. G. Gros

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引用次数: 5

摘要

几种幼体激素类似物，其中芬诺威和真JH-III，作为克氏锥虫体外培养的生长抑制剂进行了试验。同样的化合物也被用于抑制氚标记胸腺嘧啶并入T.克氏细胞。结果表明，这些含硫的类似物对细胞发育具有重要的抑制作用。对剩余的fenoxy- fenoxy衍生物也发现了有趣的抑制值。

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Biological activity of synthetic juvenile hormone analogues (JHA) for Trypanosoma cruzi

Several juvenile hormone analogues, among them Fenoxycarb and authentic JH-III, were tested as growth inhibitors for Trypanosoma cruzi cultivated in vitro. The same compounds were also assayed for inhibition of tritium labelled-thymidine incorporation into T. cruzi cells. The results indicated that those analogues containing sulfur showed important activity against the development of the cells. Interesting inhibition values were also found for the remaining fenoxy- fenoxy derivatives assayed.

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来源期刊

Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences 化学-无机化学与核化学

CiteScore

1.80

自引率

12.50%

发文量

期刊介绍： Zeitschrift fuer Naturforschung B (ZNB) publishes novel research in all areas of inorganic chemistry, organic chemistry, and analytical chemistry. In particular, the journal focuses on solid state chemistry, coordination chemistry, main group element chemistry, synthetic organic chemistry, natural product chemistry and, to a lesser extent, on analytical chemistry. For more than 65 years Zeitschrift fuer Naturforschung B has been open to contributions from all fields of experimental and theoretical chemistry. Zeitschrift fuer Naturforschung B publishes 12 issues per volume/year. Sometimes double issues occur. Topics Solid state chemistry Coordination chemistry Main group element chemistry Organic chemistry Natural product chemistry.