一种新型两相水凝胶体系的表征和药物释放控制

Thomas J. Smith, J. Kennedy, C. Higginbotham
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引用次数: 0

摘要

在这项工作中,通过将干燥凝胶物理嵌入冷冻凝胶的核心,制备了两相水凝胶体系。用聚乙烯醇(PVA)和聚丙烯酸(PAA)制备低温凝胶,用1-乙烯基-2-吡啶酮(NVP)、丙烯酸(AA)和不同比例的布洛芬钠盐进行紫外聚合制备干凝胶。采用平行板流变法和差示扫描量热法(DSC)测定了材料的力学和热性能。结果表明,在30 ~ 80℃的测试温度下,含有更高浓度PAA(在干凝胶中)的水凝胶比单独使用PVP合成的水凝胶要硬得多。利用衰减全反射傅立叶变换红外光谱(ATR-FTIR)对水凝胶的化学结构进行了确证。在所有情况下,药物溶出度分析表明,含有丙烯酸的水凝胶释放活性药物的速度较慢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterisation and controlled drug release from a novel two-phase hydrogel system
In this work, a two-phase hydrogel system was prepared by physically imbedding a xerogel in the core of a cryogel which was freeze thawed. The cryogels were prepared with poly (vinyl alcohol) (PVA) and poly (acrylic acid) (PAA) while the xerogels were prepared by UV polymerisation of 1-vinyl-2-pyrrolidinone (NVP), acrylic acid (AA) and various percentages of ibuprofen sodium salt. Mechanical and thermal properties were determined by parallel plate rheometry and differential scanning calorimetry (DSC). The results indicated that hydrogels which contained increased percent concentrations of PAA (in the xerogel) were significantly stiffer than those synthesised using PVP alone at test temperatures between 30 and 80°C. The chemical structure of the hydrogels was confirmed by means of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). In all cases, drug dissolution analysis showed that the active agent was released at a slower rate with hydrogels that contained acrylic acid.
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