NEW PLASTIC MATERIAL FOR THE TREATMENT OF VERTEBRAL PATHOLOGY AND NOT ONLY...

The paper presents results of the author’s multi-year research in the field of cellular technologies. The differentiation stages of the chondro-osseous graft are described based on the findings of morphological, ultrastructural, and molecular genetic studies. The stages of cell transformation, dynamics of synthetic processes and matrix formation are identified. Hypotheses of the histogenesis of initial stages of different types of bone tissue, and the formation of microcirculatory and vascular beds in the process of osteogenesis are suggested. Experimental testing of regenerative potentialities of the bone graft in animals has shown that it is a primitive bone tissue with a high potency to proliferation, formation and differentiation into definitive bone tissue within a transplant zone.